Maître de conférences, HDR

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5
Tour 33-43, 5ème étage
Equipe E-POM
Tel : 33 (0)1 44 27 37 21

Membre de la SCF – division chimie de coordination 
Membre de l’Association Française de RPE (ARPE)
Membre du GDR Solar Fuels
Membre du GIS Frenchbic

Thèmes de Recherche

hybrides organiques-inorganiques, réactions de transfert d’électrons, activation de petites molécules, photosynthèse artificielle, études physicochimiques (spectro-électrochimie, Résonance Paramagnétique Electronique,..), interactions POM-peptides

Résultats Récents

Interaction POMs-Peptide amyloïdes

Collaborations :
Dr. C. Hureau, équipe Alambic, LCC-Toulouse 
Pr. N. Giraud, LCBPT, Université de Paris
Financement : ANR Supramy

  • Modulation de l’agrégation de peptides amyloides par les POMs ; inhibition de la production de ROS associée aux adduits Cu(II)-amyloid

Two Keggin polyoxometalates were used as new copper ligands to counteract the effects of CuII(Amyloid-β) interaction. Their ability to remove CuII from CuII(Amyloid-β), to stop CuII(Amyloid-β) induced formation of reactive oxygen species and to restore apo-like self-assembly of CuII(Amyloid-β) was shown. Chem.Commun. 2022

Photosynthèse artificielle (A. Proust, G. Izzet, S. Blanchard)

Dr. V. Artero et Dr. M. Chavarot-Kerlidou, équipe Solhycat, CEA Grenoble
Pr. M. Fontecave, LCPB, Collège de France 
Dr. F. Bédioui, UTCBS, ChimieParisTech
Financement : ANR Photocarb
Financement : ANR Carbiored

  • Modulation de la vitesse de transfert d’électron dans une diade POM-Bodipy

The intramolecular photoinduced electron transfer of a series of polyoxometalate (POM)-bodipy hybrids was examined. The data show that both solvents and counterions have a major impact on the relaxation dynamics of the excited states by modifying the solvation shell around the POM. The experimental findings were corroborated with a computational investigation combining DFT and molecular dynamics simulation methods. Inorg. Chem. Front., 2021

  • POM comme médiateur redox dans des transferts photoinduits

The amplification effect of POMs on the efficiency of dye-sensitized nano-ITO cathodes is disclosed. POM-COOH has a substantial effect on the photocurrent response with up to 25-fold increase. Besides ensuring the stability toward leaching, the nature of the anchoring function of the POM hybrids play an intricate role in the competition between the various electron transfer pathways involved. ACS. Appl. Energy Mater. 2020

  • Réduction électrocatalytique du CO2 par des dérivés de polyanions

Metal complexes with polypyridyl ligands, among which the [Cp*Rh(bpy)Cl]+ and [M(bpy)(CO)3X] (M = Re, Mn) complexes, are well represented as catalyst for the conversion of CO2 to fuel. As a redox non-innocent ligand, the bipyridine ligand is generally involved in the reduction mechanisms. It is thus tempting to replace it by other redox non-innocent ligands such as vacant polyoxometalates (POMs). [α-H2PW11O39RhIIICp*(OH2)]3– activity towards CO2 reduction has been assessed in acetonitrile in the presence of water. VIP, Eur. J. Inorg. Chem. 2019

Complexes de ligands non-innocents et applications en catalyse bioinspirée

Collaborations : 
Pr. M. Desage-El Murr, équipe OMECA, Univ. de Strasbourg
Dr. M. Orio, ISM2, Aix-Marseille Univ.
Dr. H. Vezin, LASIR, Univ. Lille
Financement : ANR Unilversal

  • Copper complex in an entatic state

In enzyme, the entatic state model states that a strongly distorted geometry induced by ligands around a metal center gives rise to an energized structure called entatic state, strongly improving the reactivity. A highly strained redox-active ligand enables a copper complex to perform catalytic nitrogen- and carbon-group transfer in as fast as 2 min, thus exhibiting a strong increase in reactivity compared with its unstrained analogue. iScience, 2020

  • Complexes Cu-iminosemiquinoe et fluxionalité de spin

Metalloenzymes routinely perform multielectronic transformations using multistate reactivity and redox cofactors but this behavior is difficult to emulate in synthetic systems. We report a rare example of molecular spin catalysis in the context of copper-catalyzed aziridination. The molecular spin fluxionality enabled by the redox-active ligands is central to this behavior. Chem.Eur. J. 2018

Parcours Scientifique

  • Depuis sept. 2005 : Maître de Conférences Sorbonne Université (HDR en 2017), équipe Edifices Polymétalliques, IPCM UMR 8232
  • Avr. 2005-Août 2005 : Stage post-doctoral au Département des sciences du Vivant, CEA Saclay, direction Dr. C. Vita : complexation par des peptides modèles du motif EF-hand de la calmoduline
  • 2002-2004 :Stage post-doctoral au Max Planck Institut fuer Bioanorganische Chemie (Muelheim an der Ruhr, Allemagne) , direction Pr. Karl Wieghardt : structure électronique de complexes de ligands potentiellement non-innocents
  • 1999-2002 :Thèse de doctorat, université Paris 11-Orsay, direction Pr. J.-J. Girerd et Dr. G. Blondin : Complexes Ruthénium-Manganèse pour la photosynthèse artificielle
  • 1998-1999 : Service Militaire en Coopération à l’Université du Delaware, direction Pr. K. Theopold : activation de O2 par des complexes trispyrazolylborate-Co
  • 1996-1997 : DEA Multinational de Chimie Moléculaire (Ecole Polytechnique), direction du stage Pr. O. Reinaud (ChimieParisTech) : complexes Calixarène-Cuivre comme modèle d’enzymes à cuivre
  • 1992-1997 : Ingénieur de l’Ecole Supérieure de physiques et de Chimie Industrielle de la ville de Paris (ESPCI ParisTech)

Choix de publications

  1. Keggin-type Polyoxometalates as Cu(II) chelators in the context of Alzheimer’s disease
    E. Atrián-Blasco, L. de Cremoux, X. Lin, R. Mitchell-Heggs, L. Sabater, S. Blanchard*, C. Hureau*, 
    Chem. Commun. 2022, 2367-2370 ; https://doi.org/10.1039/D1CC05792H
  2. Acid-triggering of light-induced charge-separation in hybrid organic/inorganic molecular photoactive dyads for harnessing solar energy 
    E. Benazzi, J. Karlsson, Y. Ben M’Barek, P. Chabera, S. Blanchard, S. Alves, A. Proust, T. Pullerits, G. Izzet*, E. A. Gibson*, 
    Inorg. Chem. Front., 2021, 1610-1618 ; https://doi.org/10.1039/D0QI01368D
  3. Tuning Photoinduced Electron Transfer in POM-bodipy Hybrids by Controlling the Environment, Experiment and Theory
    G. Toupalas, J. Karlsson, F. A. Black, A. Masip-Sánchez, X. López, Y. Ben M’Barek, S. Blanchard, A. Proust, P. Chabera, I. P. Clark, T. Pullerits, J. M Poblet*, E. A. Gibson*, G. Izzet*, 
    Ang. Chem. Int. Ed., 2021, https://doi.org/10.1002/anie.202014677 ; 
  4. Optimizing Group Transfer Catalysis by Copper Complex with Redox-active ligand in an Entatic State
    Y. Ren, J. Forte, K. Cheaib, N. Vanthuyne, L. Fensterbank, H. Vezin, M. Orio, S. Blanchard, M. Desage-El Murr, 
    iScience, 2020, 23, 100955. https://doi.org/10.1016/j.isci.2020.100955 
  5. Dye-Sensitized Photocathodes : Boosting Photoelectrochemical Performances with Polyoxometalate Electron Transfer Mediators 
    Y. Ben M’Barek ; T. Rosser, J. Sum, S. Blanchard, F. Volatron, G. Izzet, R. Salles, J. Fize, M. Koepf, M. Chavarot-Kerlidou, V. Artero, A. Proust, 
    ACS Appl. Energy Mater., 2020, 3, 1, 163-169 ; https://doi.org/10.1021/acsaem.9b02083
  6. Assessing the electrocatalytic properties of the Cp*Rh(III)2+-Polyoxometalate derivative[H2PW11O39Rh(III)Cp*(OH2)]3- towards CO2 reduction
    M. Girardi, D. Platzer, S. Griveau, F. Bedioui, S. Alves, A. Proust,* S. Blanchard*
    VIP in Eur. J. Inorg. Chem., 2019,26, 387-393 https://doi.org/10.1002/ejic.201800454
  7. Modeling the Oxygen Vacancy at a Molecular Vanadium(III) Silica–Supported Catalyst
    T. Zhang, A. Solé-Daura, S. Hostachy, S. Blanchard, C. Paris, Y. Li, J. Carbó, J. Poblet, A. Proust, G. Guillemot,
    J. Am. Chem. Soc., 2018,140, 14903-14914,  https://doi.org/10.1021/jacs.8b09048
  8. Copper-catalyzed aziridination with redox-active ligands : molecular spin catalysis
    Y. Ren, K. Cheaib, H. Vezin, M. Orio, L. Fensterbank, S. Blanchard, M. Desage-El Murr, 
    Chem. Eur. J. 2018, 24(20), 5086-5090. https://doi.org/10.1002/chem.201705649
  9. Circumventing metallic intrinsic reactivity : radical generation with redox-active ligands
    J. Jacquet , K. Cheaib, Y. Ren, H. Vezin, M. Orio, S. Blanchard, L. Fensterbank, M. Desage-El Murr,
    Chem. Eur. J. 2017, 23, 15030-15034. https://doi.org/10.1002/chem.201704049

Liste des publications sur HAL