Pascal PIGEON

Doctor, research engineer

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 33-43, 4th floor
CHEMBIO Group
Phone:

Also staff member of Ecole Nationale Supérieure de Chimie de Paris (ENSCP-Chimie-ParisTech, member of PSL)
http://scholar.google.fr/citations?user=JA7gN3sAAAAJ (citations : >3450, h-index : 34).

Pascal Pigeon (0000-0001-5374-5346) – ORCID

ResearchGate

Research interests

Medicinal organometallic chemistry, Organometallic and organic synthesis.

Current research

  • Synthesis of organométallic compounds (ferrocene).
  • Synthesis of molecules having anticancer activity, antibacterial effect or having activity against plant diseases.
  • Synthesis of molecules bearing organométallic and heterocyclic moieties: chemical reactivity and anticancer activity.

Selected recent results

Special event

Article in the IPCM newsletter:
Pascal Pigeon (Chembio Team) inaugurates the « Recherche Data Gouv Sorbonne Université space »
first dataset was deposited on the institutional space by Pascal Pigeon (IPCM). It is described with complete documentation (rich metadata and a very detailed Readme file). This dataset is linked to an article under review and a source code deposited on HAL and archived on Software Heritage.
See the short article here.

UPDATE: The scientific article is now published in International Journal of Molecular Science (Int. J. Mol. Sci. 2023, 24, 12288. doi: 10.3390/ijms241512288.).

Scientific career

  • Studies in chemistry at University of Rouen
  • Ph. D. thesis (chemistry) under the supervision of Pr. Bernard Decroix (University of Le Havre 1996)
  • Assistant-engineer at ENSCP (Paris 1999-2001)
  • Research ingeener at ENSCP (Paris 2001-today). Linked to IPCM (Paris 2014-today)

Journal Covers

Front cover
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Selected publications

  1. Anne Vessières, Siden Top, Pascal Pigeon, Elizabeth Hillard, Leila Boubeker, Daniela Spera, and Gérard Jaouen. Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of anti-proliferative effects in vivo. J. Med. Chem., 2005, 48, 3937-3940.
  2. Yong Wang, Marie-Aude Richard, Siden Top, Patrick M. Dansette, Pascal Pigeon, Anne Vessières, Daniel Mansuy, Gérard Jaouen. Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents : Synthesis, Metabolic Formation from Ferrociphenols and Oxidative Transformation
    Angew. Chem. Int. Ed. 2016, 55, 10431-10434.
  3. Yong Wang, Pascal Pigeon, Siden Top, Michael J. McGlinchey, Gérard Jaouen
    Organometallic Antitumor Compounds : Ferrocifens as Precursors to Quinone Methides.
    Angew. Chem. Int. Ed. 2015, 54, 10230-10233.
  4. Pascal Pigeon, Yong Wang, Siden Top, Feten Najlaoui, Maria Garcia Alvarez, Jérôme Bignon, Michael McGlinchey, Gerard Jaouen. A new series of succinimido-ferrociphenols and related heterocyclic species induce strong antiproliferative effects, especially against ovarian cancer cells resistant to cisplatin. J. Med. Chem. 2017, 60, 8358-8368.
  5. Yong Wang, Pascal Pigeon, Siden Top, Juan García, Claire Troufflard, Ilaria Ciofini, Michael McGlinchey, Gerard Jaouen Atypical lone pair-π interaction with quinone methides in a series of imido-ferrociphenol anticancer drug candidates. Angew. Chem. Int. Ed. 2019, 58, 8421-8425.
  6. Pascal Pigeon, Marie Gaschard, Mohamed Othman, Michèle Salmain, Gérard Jaouen. α-Hydroxylactams as Efficient Entries to Diversely Functionalized Ferrociphenols : Synthesis and Antiproliferative Activity Studies. Molecules, 2022, 27, 14, 4549.

List of publications in Hal