Transition-Metal-Free Synthesis of Enantioenriched Tertiary
and Quaternary α-Chiral Allylsilanes
Access to enantioenriched tertiary and quaternary α-chiral allysilanes without any transition-metal catalyst is reported. This was achieved by enantioselective allylic displacement of γ-silylated allylic bromides through Lewis base activation of Grignard reagents by a bidentate chiral NHC ligand. The process afforded both high γ-regio- and enantioselectivity and is compatible with a wide range of silyl groups on the substrates.
Pérez Sevillano, R.; Ferreira, F.; Jackowski,
Chem. Eur. J. 2023, e202302227