Synthesis of original heteroaromatic molecules and study of their biological and optical properties by Candice Botuha, teacher-researcher at IPCM (ChemBio team)

To be found in the “My research project in 180 words” section of the Sorbonne University Chemistry Department’s newsletter of 30 March 2023.

Within the ChemBio team of the IPCM, my research work focuses on the design of bioactive molecules and fluorescent molecules for imaging. u003cbru003eAs an organic chemist specialised in heterocyclic chemistry, I am particularly interested in the synthesis of molecules with a novel heteroaromatic skeleton, both for the synthetic challenge and for the study of their properties. u003cbru003eAs a medicinal chemist, the search for new effective chemical series is a perpetual quest. To enrich the chemical libraries of screening molecules and to increase the chances of finding “hits”, it is essential to explore the unknown chemical space. With the help of computational chemistry and virtual design, new heterocyclic molecules have been created and innovative synthetic routes have been developed. 

Thus, several original and versatile molecules such as 1,6-naphthyridin-7(6H)-ones and 2-hydroxy(hetero)aryl-1,2,4-triazoles have been synthesised and functionalised in the laboratory. These molecules have shown remarkable properties for applications as imaging probes (dual emission, ESIPT, solvatochromism) but also promising therapeutic properties (cancer and Alzheimer disease).