Sorbonne University’s advanced inter-laboratory NMR platform gets a makeover

The SESAME RMN PARIS project (Advanced Inter-laboratory NMR Platform at Sorbonne University), jointly supported by the Federation of Molecular Chemistry (CMPC – FR 2769) and the Federation of Chemistry and Materials (FCMat – FR 2482) has received a grant of 800 k€ from the Ile de France region for the renovation of its equipment.

The electronic consoles of four instruments* have been modernized and technological innovations will be implemented: a helium-cooled 1H/13C/15N/19F cryoprobe for the 600 MHz spectrometer, a BBO-type nitrogen-cooled cryoprobe for the 500 MHz spectrometer, new electronics at 400 MHz and a self-tuning solid state probe for the 700 MHz spectrometer.
These new equipments will bring a gain in productivity and sensitivity (S/N4 with a He cryoprobe and S/N2 with an N2 cryoprobe) that meets the demands in liquid and solid NMR, whether for molecular chemistry and biomolecules, in materials science, or industrial problems. These latest technological innovations guarantee an optimal operation of the NMR platform, both technically and scientifically.

Renewal of the 400.SB spectrometer: a fruitful collaboration with the company JEOL

In order to demonstrate the feasibility of such a project to the community and to solve the electronic problems of the aging console of this spectrometer between the Federation of Molecular Chemistry of Paris Centre “CMPC” and the Federation of Chemistry and Materials of Paris Centre “FCMat” have chosen to establish a partnership with the company Jeol**.

This collaboration resulted in the installation, in 2022, of an electronic console ECZ400S which controls the original Bruker magnet and a ROYALPROBE HFX probe.

The extremely compact ECZ400S electronic console is equipped with JEOL’s new intelligent transceiver system. This new console guarantees high stability and accuracy of the measurement system and allows 1D and 2D homo- and heteronuclear, DOSY, NUS or quantitative NMR experiments.

The ROYALPROBE HFX probe, roughly equivalent to the BBFO probe proposed by Bruker (same nuclei studied and routine experimental sequences), is the only one that allows to work simultaneously on the 1H, 19F and X channels.

The simultaneous presence of these two new elements will allow to record X-1H19F, 1H-19F and 19F-1H spectra. This progress will simplify the readability of the spectra of fluorinated molecules, which are often complex because of the numerous coupling constants with neighboring nuclei.

The NMR engineers of the platform, recently trained to use this new instrument, have just opened the access to the scientific community.

(*) The spectrometers concerned operate at frequencies of 400 MHz and 600 MHz for the Federation of Molecular Chemistry, 500MHz and 700MHz for the Federation of Chemistry and Materials.

(**) JEOL is a world leader in the fields of scanning electron microscopy (SEM), transmission electron microscopy (TEM), sample preparation, mass spectrometry and NMR spectrometry.

Claire Trouffard
Regina Maruchenko