The GOBS group is delighted to welcome Professor Andrei K. Yudin from October 7 to 18, 2024.
Prof. Andrei Yudin will give a seminar
October, 16th 2024
11 am
Pierre and Marie Curie Campus
Esclangon Building
Amphi Astier
Abstract
Understanding conformation/property relationship is a fundamental challenge in the development of bioactive macrocycles. To meet this objective, chemists have resorted to various strategies, the most common of which is the use of unnatural amino acids. We have been investigating the effect of heterocyclic grafts on the properties of macrocycles. This lecture will outline the conceptual framework for our work in this field and will show how we approach reaction development aimed at the synthesis of novel macrocyclic scaffolds.
Some publications:
Illuminating the Dark Conformational Space of Macrocycles Using Dominant Rotors
Nat. Chem. 2021, 13, 218-225
Synthetic Half-Reactions
Chem. Sci. 2020, 11, 12423-12427
Amine Hemilability Enables Boron to Mechanistically Resemble Either Hydride or Proton
Nat. Chem. 2018, 10, 1062-1070
Biography:
Professor Andrei K. Yudin holds a Canada Research Chair in Medicine by Design at the University of Toronto. He received his B.Sc. from Moscow State University in 1992 and his Ph.D. from the University of Southern California under Professors G. K. Surya Prakash and George A. Olah in 1996. He then took up a postdoctoral position in the laboratory of Prof. K. Barry Sharpless at the Scripps Research Institute. In 1998, he began his independent career at the University of Toronto. He gained tenure early, becoming Associate Professor in 2002, and was promoted to Full Professor in 2007. He is currently Associate Editor of Chemical Science, where he handles submissions in the field of organic chemistry.
Contact IPCM :
Matthieu Sollogoub
Andrei K. Yudin