Sylvain ROLAND

Associate professor, HDR

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 42-43, 5th floor
GOBS Group
Phone: 33(0)1 44 27 55 67
Fax: 33(0)1 44 27 55 04

Research interests

Organic synthesis, homogeneous catalysis, ligands for catalysis, bioorganometallic chemistry, nanoparticles.

Current research

  • N-heterocyclic carbenes (NHC) and NHC-metal complexes (metal = Cu, Ag, Pd, …). Preparation of new complexes and precursors.
  • Use of NHC-metal complexes in homogeneous catalysis (M = Pd). Development of new catalytic systems.
  • Antibacterial and anticancer activity of NHC-metal complexes.

Selected recent results

  • Amination and allylic alkylation using [(NHC)Pd(allyl)Cl]/PPh3 systems Development of fast reactions in biphasic media. Structure of the complexes and role of phosphine.
  • Allylation of carbonyl derivatives catalysed by [(NHC)(PR3)PdX2] and [(NHC)Pd(allyl)Cl] complexes, in the presence of diethylzinc. Scope and limitations, experimental study of the mechanism, development of an asymmetric version.
  • Demonstration of the antibacterial activity of NHC-Ag complexes on resistant strains of S. aureus and of a synergistic effect with ciprofloxacin.
  • Demonstration of the anticancer activity of NHC-Ag complexes on different cell lines, including chemotherapy-resistant cell lines. First elucidation of the anticancer mechanism of action of silver(I) complexes.

Scientific career

  • Studies in Biochemistry and Chemistry at the University P. et M. Curie, Paris 6
  • Thesis at the Ecole Nationale Supérieure de Chimie de Paris under the supervision of Pr. J.-P. Genêt
  • Post-doctoral fellowship at University College London under the supervision of Pr. W.B. Motherwell

Selected publications

  1. Asymmetric synthesis with N-heterocyclic carbenes. Application to the copper catalyzed conjugate addition. A. Alexakis,* C.L. Winn, F. Guillen, J. Pytkowicz, S. Roland,* P. Mangeney Adv. Synth. Catal. 2003345, 1–5.
  2. Allylic amination using well-defined (NHC)Pd(η3-allyl)Cl complexes and PPh3. S. Roland,* W. Cotet, P. Mangeney Eur. J. Inorg. Chem2009, 1796–1805.
  3. Diethylzinc-mediated allylation of carbonyl compounds catalyzed by [(NHC)(PR3)PdX2] and [(NHC)Pd(η3-allyl)Cl] complexes. A. Flahaut, K. Toutah, P. Mangeney, S. Roland* Eur. J. Inorg. Chem. 2009, 5422–5432
  4. Investigation of a Series of Silver-NHCs as Antibacterial Agents : Activity, Synergistic Effects and Cytotoxicity. S. Roland, C. Jolivalt, T. Cresteil, L. Eloy, P. Bouhours, A. Hequet, V. Mansuy, C. Vanucci, J.-M. Paris Chem. Eur. J. 201117, 1442–1446.
  5. Anticancer activity of silver–N-heterocyclic carbene complexes : Caspase-independent induction of apoptosis via mitochondrial Apoptosis Inducing Factor (AIF). L. Eloy, A.-S. Jarousse, M.-L. Teyssot, A. Gautier, L. Morel, C. Jolivalt, T. Cresteil, S. Roland ChemMedChem 2012, DOI :10.1002/cmdc.201200055