Bernold HASENKNOPF

Professor

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 42-43, 5th floor
GOBS Group
Phone: 33(0)1 44 27 91 65

Research interests

Supramolecular chemistry, Coordination chemistry, Inorganic and organic synthesis, Metal complexes in biology.

Current research

  • Cyclodextrin Rotaxanes
  • Molecular Machines
  • Functionalized Polyoxometallates

Selected recent results

  • Rotaxane for bimodal medical imaging
  • Directional movement of cyclodextrin
  • Polyoxometalate-DNA conjugate

Curent positions

  • since 03/2022: Senior Advisor for European Commitment – President’s Office, Sorbonne University
  • since 12/2020: President of the Academic Council of the 4EU+ European University Alliance
  • since 04/2016: Steering committee for innovative teaching, UPMC-SU. Responsible for teacher training

Scientific career

  • 09/97-present: Professor at Sorbonne University (former University Pierre and Marie Curie) Paris
    Currently Professeur classe exceptionnelle 2 (highest rank for university professor), Paris Institute for Molecular Chemistry, CNRS UMR 8232
    Since 05/2016: member of GOBS team
    01/2009-05/2016 : Head of the supramolecular chemistry team, Institut Parisien de Chimie Moléculaire UMR 7201.
    09/97-12/08: Laboratory of Inorganic Chemistry and Molecular Materials, UMR 7071, member of the Polyoxometalate team.
  • 11/2005
    Habilitation to direct research, Pierre and Marie Curie University, 
    Title : Functionalized polyoxometallates: from supramolecular assembly to nanobiotechnologies.
  • 10/96 – 08/97
    Post-doc: University of California, Berkeley (USA): 1. phage display of catalytic antibodies (vector construct and substrate synthesis); 2. dimerization of unnatural biopolymers (library screening of oligomers).
    Director: Prof. Peter G. Schultz
  • 1993-1996
    European PhD in supramolecular chemistry, University Louis Pasteur, Strasbourg,
    Supervisor: Jean-Marie Lehn, Title: Heterohelicates and circular helicates.
  • 1987-1993
    Studies in chemistry at the University of Cologne, the University of Strasbourg and Imperial College, London.

Selected publications

  1. A molecular information ratchet using a cone-shaped macrocycle. E. Liu, S. Cherraben, L. Boulo, C. Troufflard, B. Hasenknopf, G. Vives, M. Sollogoub. Chem 2023, 9, 1147-1163.
  2. Size-dependent compression of threaded alkyldiphosphate in head to head cyclodextrin [3]pseudorotaxanes. J. Scelle, H. Vervoitte, L. Bouteiller, L. M. Chamoreau, M. Sollogoub, G. Vives, B. Hasenknopf. Chem. Sci. 2022, 13, 2218-2225.
  3. Precise Rate Control of Pseudorotaxane Dethreading by pH-Responsive Selectively Functionalized Cyclodextrins. S. Cherraben, J. Scelle, B. Hasenknopf, G. Vives, M. Sollogoub. Org. Lett. 2021, 23, 7938-7942.
  4. Dual switchable molecular tweezers incorporating anisotropic Mn-III-salphen complexes. B. Doistau, L. Benda, J. L. Cantin, O. Cador, F. Pointillart, W. Wernsdorfer, L. M. Chamoreau, V. Marvaud, B. Hasenknopf, G. Vives. Dalton Trans. 2020, 49, 8872-8882.
  5. Substrate-dependent allosteric regulation by switchable catalytic molecular tweezers. L. Benda, B. Doistau, C. Rossi-Gendron, L. M. Chamoreau, B. Hasenknopf, G. Vives. Commun. Chem. 2019, 2, doi: 10.1038/s42004-019-0246-9.
  6. Electrochemical primer extension based on polyoxometalate electroactive labels for multiplexed detection of single nucleotide polymorphisms. N. Chahin, L. A. Uribe, A. M. Debela, S. Thorimbert, B. Hasenknopf, M. Ortiz, I. Katakis, C. K. O’sullivan. Biosensors & Bioelectronics 2018, 117, 201-206.
  7. Mechanostereoselective One-Pot Synthesis of Functionalized Head-to-Head Cyclodextrin [3]Rotaxanes and Their Application as Magnetic Resonance Imaging Contrast Agents. J. W. Fredy, J. Scelle, G. Ramniceanu, B.-T. Doan, C. S. Bonnet, É. Tóth, M. Ménand, M. Sollogoub, G. Vives, B. Hasenknopf. Org. Lett. 2017, 19, 1136-1139.