Polymerization-induced self-assembly (PISA) (synthesis of nanofibers)


Jutta Rieger, Fanny Coumes, François Stoffelbach

Polymerization-induced self-assembly (PISA) is nowadays a well-established technology that relies on the extension of a solvophilic reactive chain in heterogeneous polymerization conditions. An amphiphilic block copolymer is generated and concomitantly to the growth of the solvophobic block, self-assembly occurs.

In the group, we use this technology to



« Templated-PISA » and use of nanofibers

Nanofibers have many potential applications, e.g. as rheology modifiers, as surface-active stabilizers or for biomedical applications. They can be obtained by polymerization-induced self-assembly (PISA), but only under very restricted experimental conditions.

Within the ANR “PISAforFilms” project, our group has developed a robust method called “templated PISA” to enlarge the small experimental window in which nanofibers can be reached by PISA. It relies on the introduction of a supramolecular moiety, a hydrogen-bonded bis-urea sticker, in the macromolecular reversible addition fragmentation chain transfer (RAFT) agent which drives the morphology of the nano-objects produced by RAFT-mediated PISA towards the fiber morphology.