Cationic Polymerization

Permanent staff

Véronique Bennevault, Philippe Guégan

We exploit and modify the polymerization methods of 2-n-propyl, 2-isopropyl, 2-ethyl et 2-methyl-2-oxazolines to obtain functional polymers with high molar masses.

For instance, poly(2-n-propyl-2-oxazoline)s (PpOx) and poly(2-méthyl-2-oxazoline)s (PmOx) with number average polymerization degree up to 600were synthesized and functionalized with 1-(4-aminophenyl)piperazine. These polymers, thermosensitive for the PpOxs,were then grafted on gold surfaces, decorating nucleopores membrane nanopores., in collabotation with our colleagues from “université de Paris Cité” (J.C. Lacroix)  and “ENS Lyon” (F. Montel). Selective filtration of biological macromolecules, depending on the size and on the amphiphilic character of macromolecules were outlined.

In parallel, we revisit the synthesis of star (co)polymers with poly(2-oxazoline), poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline) branches with number average degree of polymerization up to 600. These star polymers were fully characterized to evidence fast initating kinetics, allowing the formation of branches with similar length. The star polymers were hydrolyzed to obtainthe corresponding poly(ethylenimine)s (PEI) which were then tested as gene transfer vectors. In order to enhance their stealth properties, we have undertaken the synthesis of double hydrophilic copolymers poly(2-alkyl-2-oxazoline)-b-polyethyleneimine. In vivo transfection studies were also performed.

Funding

  • CIFRE, Polythéragène SAS
  • ANR VINP
  • ANR CORONA

Publications