Sandra ALVES

Associate professor, HDR

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 42-43, 4th floor
CSOB Group
Tel: 33(0)1 44 27 32 64

Research topics

Development of methods based on high-resolution, high-throughput mass spectrometry for the analysis of complex mixtures.

Current research

High-throughput approaches by direct introduction of biological samples and ultra-high resolution detection for metabolome and contaminant exposure status characterization

Analytical worklfow involving cohort analysis using high resolution FTICR, statitiscal analysis allowing the extraction of discriminants variables and identification procedure of these variables (adapted from de B. Habchi, S. Alves,* S. Streel, M. Guillaume, A.-F. Donneau, B.M. R. Appenzeller, D.N. Rutledge, A. Paris,* and E. Rathahao-Paris*. Chemical Exposure Highlighted without Any A Priori Information in an Epidemiological Study by metabolomic FT-ICR-MS Fingerprinting at High Throughput and High Resolution. Chem. Res. Toxicol. In press (2023) https://doi.org/10.1021/acs.chemrestox.3c00158)

Ion mobility-mass spectrometry approach for isomer characterization in biological samples

from the separation of isomeric compounds into complex matrices to the creation of a database for increased identification
CCS Database contains over 1300 TIMSCCSN2 values for about 400 metabolites, among many isomer compounds are characterized by vey close CCS values (CCS of few %)
Characterization of oligosaccharide isomers of breast milk (HMO) by ion mobility coupled with tandem mass spectrometry)
Direct analysis using ion mobility mass spectrometry and MS/MS of breastmilk sample (adapted from A. Delvaux, E. Rathahao-Paris, B. Guillon, S. Cholet, K Adel-Patient, F Fenaille, C Junot, S Alves. Trapped ion mobility spectrometry time-of-flight mass spectrometry for high throughput and high resolution characterization of human milk oligosaccharide isomers. Acta Chimica Acta, (2021) 1180, 338878. https://doi.org/10.1016/j.aca.2021.338878
Chiral analysis of metabolites and xenobiotics
High resolution IM-MS (SIM2 stitching mode) analyses of AA enantiomers. Each AA (L and D enantiomers) was detected as a coppered non covalent clusters with L-Phe and L-Pro as chiral references

Scientific career

  • 2017: HDR (Accreditation to supervise research), Sorbonne Université
  • Since 2003: Associate professor, CSOB, Institut Parisien de Chimie Moléculaire, Sorbonne University.
  • 2002-2003: Post-doctoral studies at ETH Zurich (Eidgenössische Technische Hochschule), Switzerland) au laboratoire « Organische Chemie » under the direction of Pr. Renato Zenobi.
  • 1999-2002: PhD. thesis at Université Pierre et Marie Curie

Selected Publications

  1. B. Habchi, S. Alves, D. Jouan-Rimbaud Bouveresse, B. Appenzeller, A. Paris, D.N. Rutledge and E. Rathahao-Paris. Potential of dynamically harmonized Fourier transform ion cyclotron resonance cell for high throughput metabolomics fingerprints: control of data quality. Analytical and Bioanalytical Chemistry (2017). https://doi.org/10.1007/s00216-017-0738-3
  2. A. Delvaux, E. Rathahao-Paris, Blanche Guillon, Sophie Cholet, K Adel-Patient, F Fenaille, C Junot, S Alves. Trapped ion mobility spectrometry time-of-flight mass spectrometry for high throughput and high resolution characterization of human milk oligosaccharide isomers. Acta Chimica Acta, (2021) 1180, 338878. https://doi.org/10.1016/j.aca.2021.338878
  3. L. Bedoin, S. Alves, J-F. Lambert. Origins of life and molecular information: selectivity in mineral surface induced prebiotic amino acids polymerization. ACS Earth and Space Chemistry. (2020) 4: 1802−1812. doi: 10.1021/acsearthspacechem.0c00183 (hal-03133031)