EN-Denis LESAGE

Research engineer

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 42-43, 4th floor
CSOB group
Phone: 33(0)1 44 27 36 81

Thèmes de recherche :

Gas-Phase Chemistry : structure, energetics and reactivity of ions – study of reaction mechanisms.

Experimental approaches : mass spectrometry – ion-molecule reactions.

Theortical approaches : kinetics, RRKM/QET modeling.

Recherche actuelle :

  • Ligand electronic effect evaluation in organometallic complexes using mass spectrometry

Bond-Dissociation Energies to Probe Pyridine Electronic Effects on Organogold(III) Complexes: From Methodological Developments to Application in π‑Backdonation Investigation and Catalysis, L. Bourehil, C. Soep, S. Seng, S. Dutrannoy, S. Igoudjil, J. Forté, G. Gontard, D. Lesage, B. Bertrand, H. Dossmann, Inorg. Chem. 2023, 62, 33, 13304-13314, https://doi.org/10.1021/acs.inorgchem.3c01584

(A) Experimental (markers) and modeled (lines) survival yield curves (SY) obtained for the set of 33 complexes. The relation between measured critical energies (±1σ) and calculated bond dissociation energies (with the M06 method) is displayed for each family of complexes in (B)−(D).

Ligand effects in gold-carbonyl complexes : evaluation of the bond dissociation energies using blackbody infrared radiative dissociation, D. Gatineau, H. Dossmann, H. Clavier, A. Memboeuf, L. Drahos, Y. Gimbert, D. Lesage, Int. J. Mass Spectrom., 2021, 463, 116545, https://doi.org/10.1016/j.ijms.2021.116545

  • Kinetic and energetic aspects in mass spectrometry

Benchmarking higher energy collision dissociation (HCD) by investigation of binding energies of gas-phase host–guest complexes of hemicryptophane cages, P. Bayat, D. Gatineau, D. Lesage, A. Martinez,R. B. Cole, J. Mass Spectrom., 2022;9999:e4879, https://doi.org/10.1002/jms.4879

Arrhenius plots of H–Gref, [Host +5H]+ (triangles), and [Host +7H]+ (circles) obtained using low-energy collision-induced dissociation (CID) (dark blue) and higher energy collision dissociation (HCD) techniques (red). The Arrhenius plot of H–Gref, acquired employing the blackbody infrared dissociation (BIRD) technique (brown) and used as a reference for temperature calibration, is also displayed.

Extended kinetic method and RRKM modeling to reinvestigate proline’s proton affinity and approach the meaning of effective temperature, D. Lesage, S. Mezzache, Y. Gimbert, H. Dossmann, J.-C. Tabet, European Journal of Mass Spectrometry, 2019;25(2):219-228, https://doi.org/10.1177/146906671882205

Scientific career

  • 2022 : Habilitation à Diriger des Recherches, Sorbonne Université. Aspects cinétiques et énergétiques en spectrométrie de masse : Applications dans les domaines analytiques et en réactivité organométallique.
  • 1991 – 1995 : Thèse de Chimie Analytique de l’Université Paris VI, sous la direction du Pr. Jean-Claude Tabet.
  • 1990 : Diplôme d’Etudes Approfondies (DEA) de Chimie Analytique à l’Institut National des Sciences et Techniques Nucléaires, Saclay, Université Paris VI.

Recent publications :

  1. Mechanism of Alkyne Hydroarylation Catalyzed by (P,C)-Cyclometalated Au(III) Complexes, M. S. M Holmsen, C. Blons, A. Amgoune, M. Regnacq, D. Lesage, E. D. Sosa Carrizo, P. Lavedan, Y. Gimbert, K. Miqueu, D. Bourissou, J. Am. Chem. Soc. 2022, 144, 49, 22722–22733 https://doi.org/10.1021/jacs.2c10737
  2. Bond-Dissociation Energies to Probe Pyridine Electronic Effects on Organogold(III) Complexes: From Methodological Developments to Application in π‑Backdonation Investigation and Catalysis, L. Bourehil, C. Soep, S. Seng, S. Dutrannoy, S. Igoudjil, J. Forté, G. Gontard, D. Lesage, B. Bertrand, H. Dossmann, Inorg. Chem. 2023, 62, 33, 13304-13314 https://doi.org/10.1021/acs.inorgchem.3c01584
  3. Synthesis and Enzymatic Conversion of Amino Acids Equipped with the Silanetriol Functionality: A Prelude to Silicon Biodiversification, J. Dussart-Gautheret, J. Rivollier, C. Simon, A. De Simone, J. Berthet, S. Delbaere, R. Maruchenko, C. Troufflard, D Lesage, Y. Gimbert, G. Lemière, P. Marlière, L Fensterbank, ChemistryEurope 2023, e202300058 https://doi.org/10.1002/ceur.202300058
  4. Energetics of key Au(III)-substrate adducts relevant to catalytic hydroarylation of alkynes, M. Regnacq, D. Lesage, M. S. M. Holmsen, K. Miqueu, D. Bourissou, Y. Gimbert, Dalton Trans. 2023 https://doi.org/10.1039/d3dt02393a