Serge THORIMBERT

Professor

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 33-43, 4th floor
CHEMBIO Group
Phone: 33(0)1 44 27 30 84

Research interests

  • Organic Synthesis – Heterocyclic compounds – Bioactive compounds
  • Organometallic Chemistry – Catalysis – Artificial Metalloenzymes
  • Hybrids Materials

Current research

  • Preparation and reactivity of aromatic heterocycles 1-3

The synthesis of new chemical spaces is essential in the discovery of new molecules or systems with interesting properties. Among them, we have synthesized for the first time 2-4H-pyrido[1,3]oxazine-4-ones which proved to be essential precursors for an easy access to other heterocycles of interest. Other molecules, of the pyridopyridone and naphthyridone types, are also molecules with interesting physicochemical properties.

  • Reactivity of methyl coumalate 4-8

We are interested in the reactivity of methylcoumalate, a compound derived from biomass. This electrophile reacts with various nucleophiles and leads, via original cascade processes, to heterocyclic compounds of interest such as pyrans, trifluoromethylated benzoic derivatives, or fluorophores useful for the detection of biomolecules such as proteins or antibodies.

  • Application of Organometalic Compounds in Biology 9-12

The application of organic or organometallic molecules in biology is a subject whose scope has no limit. In particular, the synthetic chemist can contribute to prepare molecules with unexpected properties or structures. In a fruitful collaboration with B. Hasenknopf (IPCM) and C. O’Sullivan (Tarragona) we have demonstrated the possible incorporation of hybrid polyoxometalates into polymerases.

Since 2016, we have been interested in the synthesis of organometallic complexes of iridium, with anti-cancer properties, and carrying a Bodipy part, a fluorescent probe allowing to follow the internalization of the molecule within the cell.

Scientific career

  • 1993: Doctorate (PhD) of the Université P. et M. Curie in organic chemistry. Supervisor: Pr. J.P. Genêt
  • 1993-1994: Post-doctoral fellow. Max-Planck-Institut für Kohlenforschung. Pr. W.F. Maier.
  • 1994-1995: Assistant Professor. University P. et M. Curie. Pr. C. Agami.
  • 1998-1998: Academic Visitor. Imperial College. London. Pr. D. Craig.
  • 1995-: Associate professor then Full Professor (2010) @ UPMC now SU.
  • 2003: Habilitation delivered by Université P. et M. Curie
  • 2014-: Chembio Group
  • 2017-2022: Director of the Chemistry Department @ Sorbonne Université

Selected publications

  1. 3-Hydroxypyridinyl-Substituted-1,2,4-Triazoles as new ESIPT based fluorescent dyes: Synthesis and structure-fluorescence properties correlations. A. Nina-Diogo, B. Bertrand, S. Thorimbert, G. Gontard, S. Nassem-Kahn, A. Echeverri, J. Contreras-García, C. Allain, G. Lemercier, E. Luppi and C. Botuha Adv. Opt. Mat.202311, 2300336.
  2. Heteroaromatic « Rings of the Future » : Exploration of unconquered chemical space. K. Passador, S. Thorimbert, C. Botuha Synthesis 2019, 51, 384-398.
  3. Synthetic strategy studies for a concise access of functionalized pyrano[4,3-b]pyridin-7-ones : An entry to semi-rigid analogs of antihistamines. A. Beghennou, K. Passador, A. Passador, V. Corcé, S. Thorimbert, C. Botuha Eur. J. Org. Chem. 2020, 5880-5889.
  4. Preparation of substituted 2H-Pyrans via a cascade reaction from methyl coumalate and activated methylene nucleophiles. L. Chang, K. Plevová, S. Thorimbert, L. Dechoux J. Org. Chem. 2017, 82, 5499–5505.
  5. A solvent-free, base-catalyzed domino reaction towards trifluoromethylated benzenes from bio-based methyl coumalate. L. Chang, N. Klipfel, L. Dechoux, S. Thorimbert Green Chem., 2018, 20, 1491-1498.
  6. Bio-based methyl coumalate involved Morita-Baylis-Hillman reaction. L. Chang, S. Thorimbert, L. Dechoux Org. Biomol. Chem. 2019, 17, 2784-2791.
  7. Cover feature : A solvent-free, catalyst-free formal [3+3] cycloaddition dearomatization strategy : towards new fluorophores for biomolecules labelling. L. Chang, N. Fischer-Durand, G. Gontard, B. Bertrand, S. Thorimbert, L. Dechoux ChemSusChem, 2021, 14, 1821-1824.
  8. Iron catalyzed dearomatization of pyridines into annelated azepine derivatives in a one-step, three-component reaction. A. Mamontov, L. Chang, H. Dossmann, B. Bertrand, L. Dechoux, S. Thorimbert Org. Lett. 2023, 25, 256-260.
  9. Hot Paper : PCR incorporation of polyoxometalate modified deoxynucleotide triphosphates and their application in molecular electrochemical sensing of Yersinia Pestis. M. Ortiz, A. M. Debela, M. Svodobova, S. Thorimbert, D. Lesage, R. B. Cole, B. Hasenknopf, C. K. O´Sullivan Chem. Eur. J. 2017, 23, 10597-10603.
  10. Electrochemical primer extension based on polyoxometalate electroactive labels for multiplexed detection of single nucleotide polymorphisms N. Chahin, L. Uribe, A. Mehdi, S. Thorimbert, B. Hasenknopf, M. Ortiz, I. Katakis, C. O’Sullivan Biosensors and Bioelectronics 2018, 117, 201-206.
  11. Cover paper : Synthesis, photophysical properties and living cell imaging of theranostic half-sandwich iridium – BODIPY dyads. J. M. Zimbron, K. Passador, B. Gatin-Fraudet, C.-M. Bachelet, D. Plazuk, L.-M. Chamoreau, C. Botuha, S. Thorimbert, M. Salmain Organometallics, 2017, 36, 3435-3442.
  12. Insights into the antiproliferative mechanism of (C^N)-chelated half-sandwich iridium complexes. R. Ramos, J.M. Zimbron, S. Thorimbert, L.-M. Chamoreau, M. Munier, C. Botuha, A. Karaiskou, M. Salmain, J. Sobczak-Thépot Dalton Trans 2020, 49, 17635-17641.

List of publications in Hal