Candice BOTUHA

Assistant professor-HDR

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 33-43, 4th floor
CHEMBIO Group
Phone: 33(0)1 44 27 69 29

Research topics

Synthesis of new aromatic heterocycles and study of their photophysical and biological properties

Current research

  • Design, synthesis and pharmacological evaluation of Kallikrein inhibitors
  • Synthesis and study of ESIPT-type fluorophores containing a 1,2,4-triazole nucleus
  • Synthesis of fluorescent nucleoside analogues

Recent results:

Synthesis of Kallikrein inhibitors: Study of the structure-activity relationship

Collaboration Chahrazade El Amri (IBPS-SU), Vincent Corcé (Equipe Chembio, IPCM). The results are currently being published

Synthesis and study of fluorophores containing a 1,2,4-triazole with a proton transfer mechanism in the excited state (ESIPT)

Collaboration Eléonora Luppi, Julia Contreras-Garcia (LCT, Sorbonne université), Clémence Allain (Univ. Paris-Saclay), Gilles Lemercier (Univ. Reims)

3-Hydroxypyridinyl-Substituted-1,2,4-Triazoles as new ESIPT based fluorescent dyes: Synthesis and structure-fluorescence properties correlations. Nina Diogo, A.; Bertrand, B.; Thorimbert, S.; Gontard; G.; Nassem Kahn, S.; Echeverri, A.; Contreras-García, J.; Allain, C.; Lemercier, G.; Luppi, E.; Botuha, C.  Adv. Opt. Mater, 2023, 11, 2300336.

In silico design of bio-marker detection fluorescent probes. Echeverri, A.; Botuha, C.; Gómez, T.; Luppi, E.; Contreras-Garcia, J.; Cárdenas, C. Phys. Chem. Chem. Phys., 2023, 25, 28603-28611.

– Synthesis of new aromatic heterocycles

Collaboration Vincent Corcé and Serge Thorimbert (Chembio)

1H-1,2,3-triazolyl-1,6-naphthyridin-7(6H)-ones as Potential Fluorescent Nucleoside Analogues: Synthesis and Optical Properties. Beghennou, A.; Rondot, O.; Corcé, V.;Botuha, C., Molecules, 2024, 29,687.

1,6-Naphthyridin-7(6H)-ones: Synthesis and optical properties: Beghennou, A.; Gontard, G.; Dossmann, H.; Passador, K.; Thorimbert, S.; Corcé, V.; Botuha, C. Org. Biomol. Chem, 2023, 21, 2976-2982.

  • Synthetic strategy studies for a concise access to functionalized pyrano[4,3-b] pyridin-7-ones: An entry to semi-rigid analogs of antihistamines. Beghennou, A.; Passador, K.; Passador, A.; Corcé, V.; Thorimbert, S.; Botuha, C. Eur. J. Org. Chem. 2020, 36, 5880-5889
  • Heteroromatic rings of the future: Exploration of unconquered chemical space. Passador, K.; Thorimbert, S.; Botuha, C. Synthesis, 2019, 51, 384-398.

Synthesis and biological studies of transition metal complexes based on 1,2,4-triazole ligand

Collaboration Benoit Bertrand (Chembio)

A Bis‐Chelating ONO/NN Ligand for the Synthesis of Heterobimetallic Platinum(II)/Rhenium(I) Complexes: Tools for the Optimization of a New Class of Platinum(II) Anticancer Agents. Bertrand, B.; Botuha, C.; Forté, J.; Dossmann, H.; Salmain, M.; Chem. Eur. J. 2020, 26, 12846-12861.

Design of iridium complexes and study of their mechanism of action for anti-cancer applications

Collaboration Michèle Salmain (Chembio), Joelle Thépot-Sobczak (CRSA-SU)

Cytotoxic BODIPY-appended half-sandwich iridium (III) complex forms protein adducts and induces ER stress. Ramos, R. Gilles, J-F. Morichon, R. Przybylski, C. Caron, B. Botuha, C. Karaiksou, A. Salmain, M.; Thépot-Sobczak, J. J. Med. Chem. 2021, 64, 16675-16686

Scientific career

  • 2017 : Habilitation à diriger des recherches : From total synthesis to the synthesis of new small heteroaromatic molecules for biology: A journey through heterocyclic space
  • 2004 : Assistant professor, Sorbonne université, IPCM-UMR 8232.
  • 2003-2004 : Post-doctoral intership, ICSN, Gif-sur-Yvette, Joëlle Dubois Team. Synthesis of farnesyltransferase inhibitors.
  • 2002-2003 : Post-doctoral intership, Bristol University : Tim Gallagher Team. Total Synthesis of cytisine
  • 1997-2002 : Doctoral thesis in organic chemistry Geneva University directed by E. P. Kündig. Synthesis of chiral amines for asymmetric catalysis.

Selected publications

  1. 1H-1,2,3-triazolyl-1,6-naphthyridin-7(6H)-ones as Potential Fluorescent Nucleoside Analogues: Synthesis and Optical Properties. Beghennou, A.; Rondot, O.; Corcé, V.;Botuha, C., Molecules, 2024, 29,687.
  2. 3-Hydroxypyridinyl-Substituted-1,2,4-Triazoles as new ESIPT based fluorescent dyes: Synthesis and structure-fluorescence properties correlations. Nina Diogo, A.; Bertrand, B.; Thorimbert, S.; Gontard; G.; Nassem Kahn, S.; Echeverri, A.; Contreras-García, J.; Allain, C.; Lemercier, G.; Luppi, E.; Botuha, C. Adv. Opt. Mater, 2023, 11, 2300336.
  3. In silico design of bio-marker detection fluorescent probes. Echeverri, A.; Botuha, C.; Gómez, T.; Luppi, E.; Contreras-Garcia, J.; Cárdenas, C. Phys. Chem. Chem. Phys., 2023, 25, 28603-28611.
  4. 1,6-Naphthyridin-7(6H)-ones: Synthesis and optical properties: Beghennou, A.; Gontard, G.; Dossmann, H.; Passador, K.; Thorimbert, S.; Corcé, V.; Botuha, C. Org. Biomol. Chem, 2023, 21, 2976-2982.
  5. Cytotoxic BODIPY-appended half-sandwich iridium (III) complex forms protein adducts and induces ER stress. Ramos, R. Gilles, J-F. Morichon, R. Przybylski, C. Caron, B. Botuha, C. Karaiksou, A. Salmain, M. Thépot-Sobczak, J. J. Med. Chem. 2021, 64, 16675-16686.
  6. Synthetic strategy studies for a concise access to functionalized pyrano[4,3-b] pyridin-7-ones: An entry to semi-rigid analogs of antihistamines. Beghennou, A.; Passador, K.; Passador, A.; Corcé, V.; Thorimbert, S.; Botuha, C. Eur. J. Org. Chem. 2020, 36, 5880-5889.
  7. A Bis‐Chelating ONO/NN Ligand for the Synthesis of Heterobimetallic Platinum(II)/Rhenium(I) Complexes: Tools for the Optimization of a New Class of Platinum(II) Anticancer Agents. Bertrand, B.; Botuha, C.; Forté, J.; Dossmann, H.; Salmain, M.; Chem. Eur. J. 2020, 26, 12846-12861.
  8. Heteroaromatic Rings of the Future: Exploration of Unconquered Chemical Space. Passador, K.; Thorimbert, S.; Botuha, C. Synthesis, 2019, 51, 384-398

List of publications in Hal