Research director CNRS, HDR

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 33-43, 4th floor

Research interests

Applied Bioorganometallic Chemistry

  • (i) the synthesis and in vitro and in vivo study of the antitumour effects of organometallic complexes
  • (ii) infrared detection of metal carbonyl complexes used as tracers for non-isotopic CMIA (Carbonyl ImmunoAssay) and cell imaging.

Current research

1- Synthesis and study of antiproliferative effects of ferrocifen-SAHA hybrids

IC50 values of compounds on MDA-MB-231 cells after 72h

FcTam-SAHA hybrid complex has a synergistic antiproliferative effect on MDA-MB-231 cells. 
J. J. Cazares-Marinero et al. Dalton Trans. 42, 15489, (2013)

2- Simultaneous infrared and fluorescence detection of rhenium carbonyl complexes in MDA-MB-231 cancer cells

Rhenium complexes 1 and 2 are localized in the Golgi apparatus of MDA-MB-231 cells (incubation 25 µM, 1h)
S. Clède et al., Chem. Commun. 48, 7729 (2012) ; S. Clède et al., Analyst, 138, 5627 (2013).

3 – Study of ferrocifenes in vivo: growth inhibition of implanted rat glioma tumours by injection of stealthy DP1-loaded lipid nanocapsules (LNCs)

Intravenous injection of stealth LNCs (DSPE-mPEG2000 LNCs) loaded with DP1 induces significant regression of 9L cell tumours implanted in the rat flank.
A.-L. Lainé et al. Nanomedicine, nanotechnology, biology and medicine, sous presse, doi : 10.1016/j.nano.2014.05.002 (2014)

Scientific career

  • Studies at the University of Rennes I
  • Thesis in Organometallic Chemistry in Rennes under the supervision of Professor Pierre Dixneuf, defended in Rennes in 1974
  • Thesis in Biochemistry in Rennes under the supervision of Professor Pierre Jouan, defended in Rennes in 1980 Stays abroad
    • in the Spectroscopy laboratory of Professor Ian S. Butler, McGill University in Montreal, Canada (May 81, July 86, 87, 88, 89 and December 1990
    • in the laboratory of Professor Guy Leclercq, Jules Bordet Hospital in Brussels (January 1999, October 2004)
      Winner of the 2012 Elsevier Prize for Bioorganometallic Chemistry

Selected publications

  1. A. Vessières
    Metal carbonyl tracers and the ferrocifen family : two facets of bioorganometallic chemistry. _ J. Organomet. Chem. 2013734, 3-16, doi : 10.1016/j.jorganchem.2012.12.020.
  2. E. Licandro, M. Panigati, M. Salmain, A. Vessières
    Organometallic Bioprobes for Cellular Imaging. 
    In Bioorganometallic Chemistry 2nd Edtion ; Salmain, M., Jaouen, G., Eds. ; Wiley-VCH, chap. 11 ; pp 341-391 (sous presse).
  3. S. Clede, F. Lambert, R. Saint-Fort, M. A. Plamont, H. Bertrand, A. Vessières, C. Policar
    Influence of the Side-Chain Length on the Cellular Uptake and the Cytotoxicity of Rhenium Triscarbonyl Derivatives : A Bimodal Infrared and Luminescence Quantitative Study. 
    Chem. Eur. J. 201420, 8714-8722, doi : 10.1002/chem.201402471.
  4. C. Lu, J.-M. Heldt, M. Guille-Collignon, F. Lemaitre, G. Jaouen, A. Vessieres, C. Amatore : _ Quantitative Analyses of ROS and RNS Production in Breast Cancer Cell Lines Incubated with Ferrocifens. 
    Chemmedchem 2014, 9, 1286-93, doi : 10.1002/cmdc.201402016.
  5. C. Bruyère, V. Mathieu, A. Vessières, P. Pigeon, S. Top, G. Jaouen, R. Kiss
    Ferrocifen derivatives that induce senescence in cancer cells : selected examples. 
    J. Inorg. Biochem. 2014, 141, 144-151, doi : 10.1016/j.jinorgbio.2014.08.015.

List of publications in Hal