Research interests

Organometallic catalysis, domino reactions, C-H activation, biomass valorization.

Current research

The implementation of new domino reactions for the formation of complex polycyclic structures, the design of new supports for organometallic catalysts, as well as the development of new C-H activation reactions on allyl and aromatic systems, without forgetting their use for the functionalization of biomass derivatives, are among my research concerns.

Selected recent results

• Synthesis of dihydroquinolines via Pd-catalyzed domino sequence.
• Aminopalladation vs. direct allylic amination.
• Catalytic aminopalladation/dehydropalladation: efficient access to alkylidene γ-lactams.
• Synthesis of nanogels functionalized with palladium nanoparticles.
• Murai reaction on furfural derivatives.

Scientific career

• 2020: Jean Normant “Teacher-Researcher 2020” Prize awarded by the Organic Chemistry Division of the Société Chimique de France.
• June 2020: Habilitation at Sorbonne Université.
• Since September 2010: Associate Professor (Maître de Conférences) at Sorbonne Université – UPMC (Paris VI, IPCM UMR 8232). 
  Topic: Development of new transition metal-catalyzed reactions, characterized by economy of steps and/or of atoms, aiming for the synthesis of interesting heterocycles.
• 2008-2010: Postdoctoral position and ATER at Sorbonne Université – UPMC (Paris VI, IPCM UMR 8232) under the supervision of Dr. Emmanuel Lacôte and Profs. Serge Thorimbert and Bernhold Hasenknopf. 
  Topic: Synthesis of functionalized polyoxometalates.
• 2007-2008: Postdoctoral position at the Université de Montréal (Montreal, Canada) under the supervision of Prof. André B. Charette. 
  Topic: Synthesis of new hemi-labile ligands and their applications in asymmetric catalysis.
• 2004-2007: PhD in organic chemistry at ENSTA/Ecole Polytechnique (Paris, France) under the supervision of Drs. Laurence Grimaud and Laurent El Kaïm.
  Topic: Development of multicomponent reactions with isocyanides. Study of a new Ugi-Smiles coupling.

Selected publications

1. C3-Alkylation of Furfural Derivatives by Continuous Flow Homogeneous Catalysis.
   Kiala Kinkutu, G.; Louis, C.; Roy, M.; Blanchard, J.*; Oble, J.* Beilstein J. Org. Chem. 2023, 19, 582.
2. C–H Activation Based Functionalizations of Furfural Derivatives.
   Mori, A.; Curpanen, S.; Pezzetta, C.; Perez-Luna, A.; Poli, G.*; Oble, J.* Eur. J. Org. Chem. 2022, e202200727.
3. Ru-Catalyzed Carbonylative Murai Reaction: Directed C3-Acylation of Biomass-Derived 2-Formyl Heteroaromatics.
   Sala, R.; Roudesly, F.; Veiros, L. F.; Broggini, G.; Oble, J.*; Poli, G.* Adv. Synth. Catal. 2020, 362, 2486.
4. Creating diversity from biomass : a tandem bio/metal-matalysis towards chemoselective synthesis of densely substituted furans.
   Ravasco, J. M.; Monteiro, C. M.; Siopa, F.; Trindade, A. F.; Oble, J.; Poli, G.; Simeonov, S. P.; Afonso, C. A. M. ChemSusChem 2019, 12, 4629.
5. Palladium-catalyzed [3+2]-C–C/N–C bond forming annulation.
   Liu, Y.; Mao, Z.; Pradal, A.; Huang, P-Q.; Oble, J.; Poli, G. Org. Lett. 2018, 20, 4057.
6. Murai Reaction on Furfural Derivatives Enables by a Removable N,N’-Bidentate Directing Group.
   Pezzetta, C.; Veiros, L. F.; Oble, J.; Poli, G. Chem. Eur. J. 2017, 23, 8385.
7. Pd(0)-nanoparticles embedded in core-shell nanogels as recoverable catalysts for the Mizoroki-Heck reaction.
   da Costa, A. P.; Nunes D. R.; Tharaud, M.; Oble, J.; Poli, G.; Rieger, J. ChemCatChem 2017, 9, 2167.
8. Metal-catalyzed C–H activation/functionalization : the fundamentals.
   Roudesly, F.; Oble, J.; Poli, G. J. Mol. Cat. A. Chem. 2017, 426, 275.