Alexandre PRADAL

Associate researcher

Sorbonne University
4 Place Jussieu, 75252 Paris cedex 5
Tower 32-42, 4th floor, office 414
Phone : 33(0)1 44 27 41 14

Research interests

Organometallic catalysis, domino reactions, C-H activation, biomass valorization.

Scientific career

  • January 2024: Habilitation to direct research at Sorbonne University
    Topic: Towards new, more sustainable reactions for the synthesis of biologically active molecules
  • Since october 2016: Chargé de Recherche CNRS (Research associate) at Sorbonne Université – UPMC (Paris VI – IPCM UMR 8232) in Prof. Giovanni Poli’s team.
  • March-Sept. 2016: Postdoctoral position at the URCOM Laboratory in the Université du Havre (Le Havre, France) under the supervision of Dr. Catherine Taillier and Prof. Vincent Dalla.
    Topic: Gold catalysis for N-acyliminium and ynamide chemistry. Collaboration with Prof. Gwilherm Evano (ULB, Brussels).
  • Feb.-Oct. 2015: Postdoctoral position at the Pfizer Organic Synthesis Laboratory in the University of Nottingham (Nottingham, UK) under the supervision of Prof. Christopher J. Moody.
    Topic: Total synthesis of diazonamide A.
  • April 2013-Sept. 2014: Postdoctoral position at the Laboratoire de Chimie Organique in the Université Libre de Bruxelles (Brussels, Belgium) under the supervision of Prof. Gwilherm Evano.
    Topic: Copper-catalyzed coupling reactions.
  • 2009-2012: PhD in organic chemistry at the Laboratoire Charles Friedel (UMR 7223) at Chimie ParisTech (Paris, France) under the supervision of Drs Véronique Michelet and Patrick Toullec.
    Topic: Asymmetric gold- and platinum-catalyzed cycloisomerization reactions and gold-catalyzed direct C-H acyloxylation of hindered arenes.

Recent results

  • Development of new C-H functionalization reactions.

Oxidative coupling reaction between ethers ans allylsilanes by hydride abstraction.

Palladium-catalyzed synthesis of allylsulfones by allylic C-H activation.

  • Development of domino processes.

Synthesis of bicyclic scaffolds derived from octahydroindoles by a domino Tsuji-Trost/aza-Michael reaction or by a C-H alkylation/aza-Michael process.

  • Biomass valorization

Access to sorbate derivatives by a dehydrogenative cross coupling of terpenes.

Valorization of monomers deriving from biocatalytic depolymerization of lignin

  • Total synthesis of natural and/or pharmaceutical products.

We are currently working on the total synthesis of the following targets.

Selected publications

  1. Allylsulfones through Palladium-Catalyzed Allylic C-H Sulfonylation of Terminal Alkenes.
    Chen, T.; Lahbi, J.; Broggini, G.; Pradal, A.; Poli, G. Eur. J. Org. Chem. 2023, e202201493.
  2. Oxoammonium-Mediated Allylsilane-Ether Coupling Reaction.
    Carlet, F.; Bertarini, G.; Broggini, G.; Pradal, A.; Poli, G. Eur. J. Org. Chem. 2021, 2162. With Front Cover.
  3. Palladium-Catalyzed [3+2]-C-C/C-N Bond-Forming Annulation.
    Liu, Y.; Mao, Z.; Pradal, A.; Huang, P.-Q.; Oble, J.; Poli, G. Org. Lett. 201820, 4057.
  4. Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement.
    David, N. ; Pasceri, R. ; Kitson, R. R. A. ; Pradal, A. ; Moody, C. J. Chem. Eur. J. 201622, 10867.
  5. A Vinylic Rosenmund-von Braun Reaction : Practical Synthesis of Acrylonitriles.
    Pradal, A. ; Evano, G. Chem. Commun. 201450, 11907.

Other activities