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PEREZ-LUNA Alejandro
CNRS Research Director

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 32-42 4ème étage
Team ROCS

Office 410
Tel:33(0)1 44 27 55 71
Fax: 33(0)1 44 27 75 67

mail:



ORCID : orcid.org/0000-0002-5578-9024

Research interests:

Organometallic chemistry, Metal-mediated organic synthesis, asymmetric synthesis.

Current research:

  • Elementometallation reactions of alkenes and alkynes.
  • Dialkylzinc-mediated radical/polar tandem reactions.
  • Preparation and reactivity of functionnalized allenylmetallic species.
  • Chiral nucleophiles derived from N-tert-butanesulfinamide.

Recent Results:

  • Radical silylzincation reactions.
  • Preparation and reactivity of δ-chiral allenylmetallic species.
  • Dialkylzinc-mediated radical/polar tandem reactions.
  • N-tert-butanesulfinamide-derived chiral nucleophiles.
  • δ-alcoxylated allenylmetallic species.

Scientific background:

  • Since Oct. 2015: CNRS Research Director (DR 2) at Sorbonne Université - UPMC (Paris VI – IPCM UMR 8232).
  • 2012: Habilitation at Sorbonne Université – UPMC (Paris VI – IPCM UMR 8232).
    Title: New metal-mediated reactions for organic synthesis.
  • 2003-2004: Postdoctoral position at the Université de Genève (Geneva, Switzerland) under the supervision of Prof. E. Peter Kündig.
    Topic: Application of tricarbonyl arene-chromium complexes dearomatization to the synthesis of enediynes.
  • 2000-2003: PhD at the Laboratoire de Chimie Thérapeutique (Director: Prof. Henri-Phillippe Husson) in the Université René Descartes (Paris, France) under the supervision Dr. Laurent Micouin et Dr. Martine Bonin.
    Topic: Asymmetric synthesis of polysubstituted cyclopentanes by desymmetrization of cyclic hydrazides.
  • 1998-2000: Studies at Ecole Nationale Supérieure de Chimie de Paris (ENSCP, Paris, France).

Selected papers:

  1. Stereodivergent Synthesis of β-Heteroatom-Substituted Vinylsilanes by Sequential Silylzincation–Copper(I)-Mediated Electrophilic Substitution, Fopp,C.; Isaac., K.; Romain, E.; Chemla, F.; Ferreira, F.; Jackowski, O.; Oestreich, M.; Perez-Luna, A. Synthesis, 2017, 49, 724.
  2. Stereodivergent Silylzincation of α-Heteroatom-Substituted Alkynes, Fopp, C.; Romain, E.; Isaac, K.; Chemla, F.; Ferreira, F.; Jackowski, O.; Oestreich, M.; Perez-Luna, A. Org. Lett. 2016, 18, 2054.
  3. Ring-Opening of N-tert-Butanesulfinyl Ethynylaziridines with Lithium Tris(dimethylphenylsilyl)zincate: Stereoselective Access to 4-Amino-1-Allenylsilanes Bochatay, V. N.; Sanogo, Y.; Chemla, F.; Ferreira, F.; Jackowski, O.; Perez-Luna, A. Adv. Synth. Catal. 2015, 357, 2809.
  4. Asymmetric Tandem Conjugate Addition-Aldol Condensation with N-Acryloyloxazolidines derived from 2-Phenylglycinol, Zelocualtecatl-Montiel, I.; García-Álvarez, F.; Juárez, J. R.; Orea, L.; Gnecco, D.; Mendoza, A.; Chemla, F.; Ferreira, F.; Jackowski, O.; Aparicio, D. M.; Perez-Luna, A.; Terán, J. L. Asian J. Org. Chem., 2017, 6, 67.
  5. Trans-Selective Radical Silylzincation of Ynamides, Romain, E.; Fopp, C.; Chemla, F.; Ferreira, F.; Jackowski, O.; Oestreich, M.; Perez-Luna, A. Angew. Chem. Int. Ed., 2014, 53, 11333.

Full list of publications: