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OBLE Julie
Associate Professor

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 32-42 4ème étage

Office 414
Tel:33(0)1 44 27 41 14


Research interests:

Organometallic catalysis, domino reactions, C-H activation, biomass valorization.

Current research:

The implementation of new domino reactions for the formation of complex polycyclic structures, the design of new supports for organometallic catalysts, as well as the development of new C-H activation reactions on allyl and aromatic systems, without forgetting their use for the functionalization of biomass derivatives, are among my research concerns.

Recent Results:

  • Synthesis of dihydroquinolines via Pd-catalyzed domino sequence.
  • Aminopalladation vs. direct allylic amination.
  • Catalytic aminopalladation/dehydropalladation: efficient access to alkylidene γ-lactams.
  • Synthesis of nanogels functionalized with palladium nanoparticles.
  • Murai reaction on furfural derivatives.

Scientific background:

  • June 2020: Habilitation at Sorbonne Université.
  • Since September 2010: Associate Professor (Maître de Conférences) at Sorbonne Université – UPMC (Paris VI, IPCM UMR 8232).
    Topic: Development of new transition metal-catalyzed reactions, characterized by economy of steps and/or of atoms, aiming for the synthesis of interesting heterocycles.
  • 2008-2010: Postdoctoral position and ATER at Sorbonne Université – UPMC (Paris VI, IPCM UMR 8232) under the supervision of Dr. Emmanuel Lacôte and Profs. Serge Thorimbert and Bernhold Hasenknopf.
    Topic: Synthesis of functionalized polyoxometalates.
  • 2007-2008: Postdoctoral position at the Université de Montréal (Montreal, Canada) under the supervision of Prof. André B. Charette.
    Topic: Synthesis of new hemi-labile ligands and their applications in asymmetric catalysis.
  • 2004-2007: PhD in organic chemistry at ENSTA/Ecole Polytechnique (Paris, France) under the supervision of Drs. Laurence Grimaud and Laurent El Kaïm.
    Topic: Development of multicomponent reactions with isocyanides. Study of a new Ugi-Smiles coupling.

Selected papers:

  1. Metal-catalyzed C–H activation/functionalization: the fundamentals. Roudesly, F.; Oble, J.; Poli, G. J. Mol. Cat. A. Chem. 2017, 426, 275.
    Palladium-Catalyzed Arylic/Allylic Aminations: Permutable Domino Sequences for the Synthesis of Dihydroquinolines from Morita-Baylis-Hillmann Adducts, Lorion, M. M.; Gasperini, D.; Oble, J.; Poli, G. Org. Lett., 2013, 15, 3050.
  2. (Diacyloxyiodo)benzenes driven palladium-catalyzed cyclizations of unsaturated N-sulfonylamides: opportunities of path selection. Borelli, T.; Brenna, S.; Broggini, G.; Oble, J.; Poli, G. Adv. Synth. Catal. 2017, 359, 623.
  3. Pd(0)-nanoparticles embedded in core-shell nanogels as recoverable catalysts for the Mizoroki-Heck reaction. da Costa, A. P.; Nunes D. R.; Tharaud, M.; Oble, J.; Poli, G.; Rieger, J. ChemCatChem 2017, 9, 2167.
  4. Murai Reaction on Furfural Derivatives Enables by a Removable N,N’-Bidentate Directing Group, Pezzetta, C.; Veiros, L. F.; Oble, J.; Poli, G. Chem. Eur. J., 2017, 23, 8385.
  5. Toward analogs of the 2-carboxyl-6-hydroxyoctahydroindole (CHOI) unit. Mao, Z.; Martini, E.; Prestat, G.; Oble, J.; Huang, P-Q.; Poli, G. Tetrahedron Lett. 2017, 58, 4174.
  6. Pd-catalyzed direct C–H alkenylation and allylation of azine N-oxides. Roudesly, F.; Veiros, L. F.; Oble, J.; Poli, G. Org. Lett. 2018, 20, 2346.
  7. Palladium-catalyzed [3+2]-C–C/N–C bond forming annulation. Liu, Y.; Mao, Z.; Pradal, A.; Huang, P-Q.; Oble, J., Poli, G. Org. Lett. 2018, 20, 4057.
  8. Ruthenium-catalyzed C–H arylation and alkenylation of furfural imines with boronates derivatives. Siopa, F.; Ramis Cladera, V-A.; Afonso, C. A. M.; Oble, J.; Poli, G. Eur. J. Org. Chem. 2018, 6101.
  9. Switchable selectivity in Pd-catalyzed [3+2]-annulations of γ-oxy-2-cycloalkenones with 3-oxoglutarates: C−C/C−C vs C−C/O−C bond formation. Liu, Y.; Oble, J.; Poli, G. Beilstein J. Org. Chem. 2019, 15, 1107.
  10. Creating diversity from biomass: a tandem bio/metal-matalysis towards chemoselective synthesis of densely substituted furans. Ravasco, J. M.; Monteiro, C. M.; Siopa, F.; Trindade, A. F.; Oble, J.; Poli, G.; Simeonov, S. P.; Afonso, C. A. M. ChemSusChem 2019, 12, 4629.

Full list of publications:

The complete list of publications can be found on the ORCID and ResearcherID profiles.