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Doctor, research engineer

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 33-43 4ème étage. case 229
Team Chembio

Tel:33(0)1 44 27 66 99


Also staff member of Ecole Nationale Supérieure de Chimie de Paris (ENSCP-Chimie-ParisTech>, member of PSL) (citations : >3000, h-index: 32)
h-index: 31 - Citations (WOS) : >2500 - publications: 85
Patents: 3

Research interests :

Medicinal organometallic chemistry, Organometallic and organic synthesis.

Current research :

  • Synthesis of organométallic compounds (ferrocene).
  • Synthesis of molecules having anticancer activity, antibacterial effect or having activity against plant diseases.
  • Synthesis of molecules bearing organométallic and heterocyclic moieties: chemical reactivity and anticancer activity.

Recent results:

  • Study of a series of ferrocene compounds which exhibit anticancer and antibacterial activities (Journal of Organometallic Chemistry (2011), 696(5), 1038-1048).

Scientific career

  • Studies in chemistry at University of Rouen
  • Ph. D. thesis (chemistry) under the supervision of Pr. Bernard Decroix (University of Le Havre 1996)
  • Assistant-engineer at ENSCP (Paris 1999-2001)
  • Research ingeener at ENSCP (Paris 2001-today). Linked to IPCM (Paris 2014-today)

Journal Covers:

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Selected publications:

List (up to date) at :

  1. Anne Vessières, Siden Top, Pascal Pigeon, Elizabeth Hillard, Leila Boubeker, Daniela Spera, and Gérard Jaouen. Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of anti-proliferative effects in vivo. J. Med. Chem., 48, 3937-3940 (2005).
  2. Nguyen, Anh; Vessieres, Anne; Hillard, Elizabeth A.; Top, Siden; Pigeon, Pascal; Jaouen, Gerard. Ferrocifens and ferrocifenols as new potential weapons against breast cancer. Chimia (2007), 61(11), 716-724.
  3. Yong Wang, Marie-Aude Richard, Siden Top, Patrick M. Dansette, Pascal Pigeon, Anne Vessières, Daniel Mansuy, Gérard Jaouen
    Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols and Oxidative Transformation
    Angew. Chem. Int. Ed. 2016, 55, 10431-10434.
  4. Yong Wang, Pascal Pigeon, Siden Top, Michael J. McGlinchey, Gérard Jaouen
    Organometallic Antitumor Compounds : Ferrocifens as Precursors to Quinone Methides.
    Angew. Chem. Int. Ed. 2015, 54, 10230-10233.
  5. Pascal Pigeon, Yong Wang, Siden Top, Feten Najlaoui, Maria Garcia Alvarez, Jérôme Bignon, Michael McGlinchey, Gerard Jaouen. A new series of succinimido-ferrociphenols and related heterocyclic species induce strong antiproliferative effects, especially against ovarian cancer cells resistant to cisplatin. J. Med. Chem. 2017, 60, 8358-8368.
  6. Yong Wang, Pascal Pigeon, Siden Top, Juan García, Claire Troufflard, Ilaria Ciofini, Michael McGlinchey, Gerard Jaouen Atypical lone pair-π interaction with quinone methides in a series of imido-ferrociphenol anticancer drug candidates. Angew. Chem. Int. Ed. 2019, 58, 8421-8425.