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  • M. Abdellaoui, A. Millanvois, E. Levernier, C. Ollivier, and L. Fensterbank, “Visible-Light-Mediated Z-Stereoselective Monoalkylation of β,β-Dichlorostyrenes by Photoredox/Nickel Dual Catalysis”, Synlett, Jan. 2021.
    Abstract: <p>Metal-catalyzed alkylation of 1,1-dihalovinyl moiety commonly suffers from both a lack of stereoselectivity and the overreaction leading to the dialkylation product. The methodology described herein features a new pathway to alkylate stereoselectively β,β-dichlorostyryl substrates to provide the <i>Z</i>-trisubstituted olefin only with fair to good yields. This cross-coupling reaction bears on the smooth and photoinduced formation of a C-centered radical that engages in a nickel-catalyzed organometallic cycle to form the key C<sub>sp2</sub>–C<sub>sp3</sub> bond.</p>
    Tags: MACO.
    Attachment Full Text PDF 507.5 kb (source)

  • M. Balas, S. Beaudoin, A. Proust, F. Launay, and R. Villanneau, “Advantages of Covalent Immobilization of Metal-Salophen on Amino-Functionalized Mesoporous Silica in Terms of Recycling and Catalytic Activity for CO2 Cycloaddition onto Epoxides”, European Journal of Inorganic Chemistry, vol. 2021, no. 16, p. 1581-1591, 2021.
    Abstract: NiII and MnIII Schiff base complexes (Salophen-Ni and Salophen-MnCl) bearing a pending carboxylic group were prepared and characterized. Both complexes were grafted onto a mesoporous amino-functionalized SBA-15 silica, by formation of an amide function between the propylamine groups of the support and the carboxylic acid functions of the salophen ligand (corresponding respective to 1.30 wt.% of Ni and 1.06 wt.% of Mn). The co-catalytic behaviour of the free and grafted complexes was then evaluated in the CO2 cycloaddition reaction onto styrene oxide, using tetra-butylammonium bromide (n−Bu4NBr) as the main catalyst. In homogeneous conditions, the MnIII Schiff base complex and the NiII one, to a lesser extent, behave as efficient co-catalysts for this reaction (styrene conversion of 100 % and 65 % respectively after 3 h at 120 °C, under 15 bars of CO2). Upon immobilization at the surface of the amino-functionalized SBA-15, we showed that the co-catalytic activity of the less efficient one, i. e. Ni2+ salophen complex, could be enhanced (reaching a full conversion after 7 h), hence highlighting a potential synergistic effect between the unused amine functions of the support and the Ni2+ salophen co-catalyst. Both salophen complexes were successfully re-used in homogeneous conditions or after their immobilization without any appreciable loss of activity. This work is only a first step towards a completely heterogeneous catalytic system, in which the tetraalkylammonium halide catalyst and the metal-salophen co-catalyst will both be covalently anchored on the same support.
    Tags: CO2 valorization, Cyloaddition, E-POM, Hybrid catalysts, Mesoporous materials, POLE 2, Salen derivatives.
    Attachment Full Text PDF 1.2 Mb (source)

  • A. Benchohra, Y. Li, L. - M. Chamoreau, B. Baptiste, E. Elkaïm, N. Guillou, D. Kreher, and R. Lescouëzec, “The Atypical Hysteresis of [Fe(C6F5Tp)2]: Overlay of Spin-Crossovers and Symmetry-Breaking Phase Transition”, Angewandte Chemie, vol. 133, no. 16, p. 8885-8889, 2021.
    Abstract: The [FeII(C6F5Tp)2] spin-crossover complex is an atypical molecular switch, which can be converted upon annealing between two archetypal spin-crossover behaviours: from an extremely gradual spin-crossover to a broad hysteretic spin-transition (of ca. 65 K). The hysteresis shows an uncommon “rounded shape” that is reproducible upon cycling temperature. In depth structural studies reveal a first crystal phase transition, which occurs upon melting and recrystallizing at high temperature. This first irreversible transition is associated with a radical change in the crystal packing. More importantly, the “rounded and broad” hysteretic transition is shown to occur in a non-cooperative SCO system and is associated with the occurrence of a symmetry-breaking phase transition that appears when roughly ca. 50 % of the SCO complexes are switched.
    Tags: ERMMES, POLE 2.

  • F. Carlet, G. Bertarini, G. Broggini, A. Pradal, and G. Poli, “Oxoammonium-Mediated Allylsilane–Ether Coupling Reaction”, European Journal of Organic Chemistry, vol. 2021, no. 15, p. 2162-2168, 2021.
    Abstract: A new C(sp3)−H functionalization reaction consisting of the oxidative α-allylation of allyl- and benzyl- methyl ethers has been developed. The C−C coupling could be carried out under mild conditions thanks to the use of cheap and green oxoammonium salts. The scope of the reaction was studied over 27 examples, considering the nature of the substituents on the two coupling partners.
    Tags: Allylation, Benzyl ethers, C(sp3)−H functionalization, Cinnamyl ethers, Oxoammonium, ROCS.

  • L. Chang, N. Fischer-Durand, G. Gontard, B. Bertrand, S. Thorimbert, and L. Dechoux, “A solvent-free, catalyst-free formal [3+3] cycloaddition dearomatization strategy: towards new fluorophores for biomolecules labelling”, ChemSusChem, vol. n/a, no. n/a, 2021.
    Abstract: A general, sustainable dearomatization reaction for nitrogen-containing heterocycles was developed. Under solvent free conditions and without catalyst, the biorenewable methyl coumalate ( MC ) reacts as an efficient C3 partner to convert eleven types of basic aromatic rings into their pyrido[1,2-a] fused derivatives in good to excellent yields. The fluorescence properties of some of the products were harnessed to conjugate fluorescent tags to BSA and immunoglobulin G.
    Tags: CHEMBIO, dearomatization reaction, fluorescent probes, methyl coumalate, Michael addition, Nitrogen heterocycles, POLE 3.
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  • F. Chemla and A. Perez-Luna, “2.5 Radical–Polar Crossover Reactions”, in Free Radicals: Fundamentals and Applications in Organic Synthesis 2, 2021st ed., Thieme Verlag, 2021.
    Abstract: Radical–polar crossover reactions, that is, single-electron redox events allowing for the interconversion between radical and ionic intermediates, make it possible to connect radical and polar processes in the same synthetic transformation. Such a combination is the basis of much original synthetic methodology, which is particularly useful in the context of domino, tandem, or multicomponent reactions. This chapter comprehensively covers the field of radical–polar crossover reactions, with a primary emphasis on transformations wherein both the radical and polar processes provide synthetic elaboration.
    Tags: Organic Chemistry, POLE 1, ROCS.
    Attachment Snapshot 617.9 kb (source)

  • S. Curpanen, G. Poli, J. Oble, and A. Perez‐Luna, “C(sp2)−Si Bond Functionalization through Intramolecular Activation by Alkoxides”, European Journal of Organic Chemistry, vol. 2021, no. 7, p. 1055-1071, 2021.
    Abstract: Organosilicon reagents are invaluable tools in the hands of the modern chemist that allow accomplishing a number of synthetically useful transformations. While some are standard reactions, others are more complex transformations, such as the Brook rearrangement and its variants. This carbon-to-oxygen silyl migration represents a privileged method to generate transient carbanionic species well suited to undergo functionalization upon electrophilic substitution in the presence of an electrophile. This minireview focuses on recent advances in C(sp2)−Si bond functionalization through intramolecular activation by alkoxides. The key elements of reactivity will be highlighted in the introduction to allow the proper understanding of the migration process. Then, an overview of the reactivity of substrates incorporating the C(sp2)−Si motif and their synthetic applications will be provided.
    Tags: Anion Relay Chemistry, Brook rearrangement, Hiyama cross-coupling, POLE 1, ROCS, Silyl migration, Synthetic methods.
    Attachment Snapshot 484.1 kb (source)

  • H. Dossmann, L. Fontaine, T. Weisgerber, V. Bonnet, E. Monflier, A. Ponchel, and C. Przybylski, “First Steps to Rationalize Host–Guest Interaction between α-, β-, and γ-Cyclodextrin and Divalent First-Row Transition and Post-transition Metals (Subgroups VIIB, VIIIB, and IIB)”, Inorganic Chemistry, vol. 60, no. 2, p. 930-943, Jan. 2021.

  • Y. Fu, Y. Ding, L. Zhang, Y. Zhang, J. Liu, and P. Yu, “Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems”, European Journal of Medicinal Chemistry, vol. 217, p. 113372, 2021.

  • D. Gatineau, H. Dossmann, H. Clavier, A. Memboeuf, L. Drahos, Y. Gimbert, and D. Lesage, “Ligand effects in gold-carbonyl complexes: evaluation of the bond dissociation energies using blackbody infrared radiative dissociation”, International Journal of Mass Spectrometry, p. 116545, Feb. 2021.

  • A. Gillet, S. Cher, M. Tassé, T. Blon, S. Alves, G. Izzet, B. Chaudret, A. Proust, P. Demont, F. Volatron, and S. Tricard, “Polarizability is a key parameter for molecular electronics”, Nanoscale Horizons, vol. 6, no. 3, p. 271-276, Mar. 2021.
    Abstract: Identifying descriptors that govern charge transport in molecular electronics is of prime importance for the elaboration of devices. The effects of molecule characteristics, such as size, bulkiness or charge, have been widely reported. Herein, we show that the molecule polarizability can be a crucial parameter to consider. To this end, platinum nanoparticle self-assemblies (PtNP SAs) are synthesized in solution, including a series of polyoxometalates (POMs). The charge of the POM unit can be modified according to the nature of the central heteroatom while keeping its size constant. POM hybrids that display remote terminal thiol functions strongly anchor the PtNP surface to form robust SAs. IV curves, recorded by conductive AFM, show a decrease in Coulomb blockade as the dielectric constant of the POMs increases. In this system, charge transport across molecular junctions can be interpreted as variations in polarizability, which is directly related to the dielectric constant.
    Tags: E-POM, POLE 2.
    Attachment Full Text PDF 2.7 Mb (source)

  • A. Harbi, Y. L. Godec, Y. Li, H. Moutaabbid, S. Benmokhtar, and M. Moutaabbid, “Experimental and theoretical investigation of the electronic, magnetic, and optical properties of a new oxyphosphate, Ni0.25Mn0.25TiO(PO4)”, Journal of Physics and Chemistry of Solids, vol. 148, p. 109633, 2021.
    Abstract: The structural, magnetic, and optical properties of a new oxyphosphate, Ni0.25Mn0.25TiOPO4, have been investigated by X-ray diffraction (XRD) analysis, magnetic FC-ZFC measurements, and vibrational spectroscopy (Raman, IR, WDS, and UV/visible). XRD analysis showed that the compound crystallizes in a monoclinic structure, space group P21/c, with unit cell parameters of a = 7.3758(2) Å, b = 7.3255(2) Å, c = 7.3448(2) Å, and β = 120.25(2)°. Elemental analysis of the powder confirmed the presence of Ni, Mn, Ti, and P therein. Raman and IR spectra show strong bands at 749 and 787 cm−1, respectively, attributable to the vibration of –Ti–O–Ti–O– bonds in infinite chains. Magnetic studies have been performed in the temperature range from 2 to 300 K. The results revealed a weak antiferromagnetic coupling between spins in Ni0.25Mn0.25TiOPO4. The band-gap energy was estimated as Eg = 1.99 eV based on UV/Vis spectrophotometry. To better understand the experimental data, density functional theory (DFT) computations were performed within the generalized gradient approximation (GGA) and GGA + U. The partial density of states (PDOS) shows strong hybridization between O 2p, Mn 3d, and Ni 3d in the valence band and between Mn 3d, Ni 3d, and Ti 3d in the conduction band.
    Tags: ERMMES, POLE 2.

  • X. He, Y. Nie, M. Zhong, S. Li, X. Li, Y. Guo, Z. Liu, Y. Gao, F. Ding, D. Wen, and Y. Zhang, “New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations”, European Journal of Medicinal Chemistry, vol. 218, p. 113384, 2021.

  • S. C. L. Kamerlin, D. J. Allen, B. de Bruin, E. Derat, and H. Urdal, “Journal Open Access and Plan S: Solving Problems or Shifting Burdens?”, Development and Change, vol. n/a, no. n/a, 2021.
    Abstract: This academic thought piece provides an overview of the history of, and current trends in, publishing practices in the scientific fields known to the authors (chemical sciences, social sciences and humanities), as well as a discussion of how open access mandates such as Plan S from cOAlition S will affect these practices. It begins by summarizing the evolution of scientific publishing, in particular how it was shaped by the learned societies, and highlights how important quality assurance and scientific management mechanisms are being challenged by the recent introduction of ever more stringent open access mandates. The authors then discuss the various reactions of the researcher community to the introduction of Plan S, and elucidate a number of concerns: that it will push researchers towards a pay-to-publish system which will inevitably create new divisions between those who can afford to get their research published and those who cannot; that it will disrupt collaboration between researchers on the different sides of cOAlition S funding; and that it will have an impact on academic freedom of research and publishing. The authors analyse the dissemination of, and responses to, an open letter distributed and signed in reaction to the introduction of Plan S, before concluding with some thoughts on the potential for evolution of open access in scientific publishing.
    Tags: MACO.
    Attachment Snapshot 648.7 kb (source)
    Attachment Full Text PDF 275.8 kb (source)

  • G. Lemière, A. Millanvois, C. Ollivier, and L. Fensterbank, “A Parisian Vision of the Chemistry of Hypercoordinated Silicon Derivatives”, The Chemical Record, vol. 21, no. 5, p. 1119-1129, 2021.
    Abstract: Less than ten years of acquaintance with hypercoordinated silicon derivatives in our lab is described in this account. Martin's spirosilane derivatives open new opportunities as ligands and as agents for the activation of small molecules and bis-catecholato silicates have proven to be exquisite radical precursors in photoredox conditions for broad synthetic applications.
    Tags: Lewis acid, MACO, photoredox, radical, silicate, Silicon.
    Attachment Full Text PDF 2.1 Mb (source)

  • A. Lepoetre, S. Ognier, M. Zhang, J. Wengler, S. Al Ayoubi, C. Ollivier, L. Fensterbank, X. Duten, and M. Tatoulian, “Amination of Cyclohexane by Dielectric Barrier Discharge Processing in a Continuous Flow Microreactor: Experimental and Simulation Studies”, Plasma Chemistry and Plasma Processing, vol. 41, no. 1, p. 351-368, 2021.
    Abstract: A miniaturized flow device has been developed to combine microfluidics technology and plasma process. In this microreactor, atmospheric pressure dielectric barrier discharges are generated in a gas in contact with a liquid phase. This study was conducted with plasma generated in ammonia in contact with a flow of liquid cyclohexane. Cyclohexylamine was synthesized with a good selectivity, and the process can be implemented to improve conversion and effectiveness. Numerical simulations confirmed that N­ H2 radicals are generated in the plasma and react with cyclohexyls radicals to achieve the reaction, giving a selectivity of 50% and a total molar conversion of 20% of cyclohexane. The effects of voltage and frequency on the selectivity and the experimental conversion rate were studied and discussed.
    Tags: MACO.
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    J. Liu, X. Ding, Y. Fu, C. Xiang, Y. Yuan, Y. Zhang, and P. Yu, “Cyclodextrins based delivery systems for macro biomolecules”, European Journal of Medicinal Chemistry, vol. 212, p. 113105, 2021.

  • J. Liu, B. Wang, C. Przybylski, O. Bistri‐Aslanoff, M. Ménand, Y. Zhang, and M. Sollogoub, “Programmed Synthesis of Hepta‐Differentiated β‐Cyclodextrin: 1 out of 117655 Arrangements”, Angewandte Chemie International Edition, vol. 60, no. 21, p. 12090-12096, May 2021.

  • S. Mabrouk, H. Rinnert, L. Balan, S. Blanchard, J. Jasniewski, G. Medjahdi, R. B. Chaabane, and R. Schneider, “Aqueous synthesis of highly luminescent ternary alloyed Mn-doped ZnSeS quantum dots capped with 2-mercaptopropionic acid”, Journal of Alloys and Compounds, vol. 858, p. 158315, Mar. 2021.
    Abstract: Highly photoluminescent and water dispersible ternary alloyed Mn-doped ZnSeS and core/shell Mn:ZnSeS/ZnS quantum dots (QDs) with pure dopant emission were synthesized through a simple aqueous route using thiolactic acid (2-MPA) as a capping ligand. Transmission electron microscopy and X-ray diffraction show that Mn:ZnSeS nanocrystals are of spherical shape, with a diameter of 2.4 nm and a cubic zinc blende structure. With the overcoating of the ZnS shell, the particle size increases to 3.7 nm, which confirms the epitaxial growth of the shell on Mn:ZnSeS cores. The photoluminescence (PL) quantum yield depends on the Mn loading and reaches 22% for Mn:ZnSeS cores doped with 10% Mn and 41% after the growth of ZnS at the surface of the cores due to the effective elimination of surface-trap states. Mn:ZnSeS QDs exhibit also long PL lifetimes (up to 681 μs) indicating that the emission originates from the spin forbidden Mn2+ 4T1 → 6A1 transition. Electron paramagnetic resonance and X-ray photoelectron spectroscopy results suggest that Mn2+ ions are located at the interface of core/shell Mn:ZnSeS/ZnS QDs. Further, the stability of Mn:ZnSeS/ZnS QDs was also investigated along with their transfer in organic phase using octanethiol.
    Tags: 2-Mercaptopropionic acid, Core/shell Mn:ZnSeS/ZnS, E-POM, Mn-doped ZnSeS, Photoluminescence, POLE 2, Quantum dots, Stability.

  • G. Mellot, J. - M. Guigner, J. Jestin, L. Bouteiller, F. Stoffelbach, and J. Rieger, “Unexpected thermo-responsiveness of bisurea-functionalized hydrophilic polymers in water”, Journal of Colloid and Interface Science, vol. 581, p. 874-883, Jan. 2021.
    Abstract: Hypothesis Thermoresponsive polymers are important materials for various applications. However, the number of polymers that exhibit this property in the temperature range of interest remains limited. The development of novel rational design strategies through the understanding of the thermal transition’s origin is therefore of utmost importance. Experiments Bisurea-functionalized water-soluble polymers were synthesized by RAFT polymerization. After direct dissolution in water, the supramolecular assemblies were analyzed by cryo-TEM and SANS. Their temperature-dependent water-solubility was characterized by various techniques, namely DLS, SANS, DSC, IR, to understand the origin of the temperature sensitivity. Findings The supramolecular assemblies exhibit an unexpected temperature-dependent solubility. For instance, a cloud point of only 39 °C was measured for poly(N,N-dimethylacrylamide) assemblies. This property is not restricted to one specific polymer but is rather a general feature of bisurea-functionalized polymers that form supramacromolecular bottlebrushes in water. The results highlight the existence of two distinct transitions; the first one is a visually perceptible cloud point due to the aggregation of individual micelles, presumably driven by the hydrophobic effect. The second transition is related to the dissociation of intermolecular bisurea hydrogen bonds. Finally, we show that it is possible to widely tune the cloud point temperature through the formation of co-assemblies.
    Tags: Bisurea, Cloud point, Cylindrical micelles, Hydrogen bonding, LCST, nano-DSC, POLE 4, POLYMERES, Supramacromolecular assemblies, Supramolecular bottlebrushes, Thermoresponsive.

  • G. Passos Gomes, G. Xu, X. Zhu, L. ‐M. Chamoreau, Y. Zhang, O. Bistri‐Aslanoff, S. Roland, I. V. Alabugin, and M. Sollogoub, “Mapping C−H⋅⋅⋅M Interactions in Confined Spaces: (α‐ICyD <sup>Me</sup> )Au, Ag, Cu Complexes Reveal “Contra‐electrostatic H Bonds” Masquerading as Anagostic Interactions**”, Chemistry – A European Journal, p. chem.202100263, May 2021.

  • C. Przybylski and V. Bonnet, “Discrimination of isomeric trisaccharides and their relative quantification in honeys using trapped ion mobility spectrometry”, Food Chemistry, vol. 341, p. 128182, 2021.

  • E. Rathahao-Paris, S. Alves, and A. Paris, “High-Throughput Metabolomics Using Flow Injection Analysis and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry”, in Metabolomics, vol. 159, New York, NY: Humana, 2021, p. 9-23.
    Abstract: The hyphenation of flow injection analysis (FIA) with Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is an efficient approach usable to perform high throughput and very high resolution metabolomic data acquisition. Instrumental and analytical conditions for performing FIA-MS are provided. The procedure to optimize dilution factor of biological samples as well as to evaluate quality of acquisition data are also described. In this protocol, urine is chosen as a matrix example to illustrate the application of procedures. Last, some indications on an adapted data processing are given.
    Tags: CSOB, POLE 3.

  • E. Romain, K. de la Vega-Hernández, F. Guégan, J. S. García, C. Fopp, F. Chemla, F. Ferreira, H. Gerard, O. Jackowski, S. Halbert, M. Oestreich, and A. Perez-Luna, “Development of a Radical Silylzincation of (Het)Aryl-Substituted Alkynes and Computational Insights into the Origin of the trans-Stereoselectivity”, Advanced Synthesis & Catalysis, vol. 363, no. 10, p. 2634-2647, 2021.
    Abstract: Aryl- and hetaryl-substituted acetylenes undergo regio- and stereoselective silylzincation by reaction with [(Me3Si)3Si]2Zn in the presence of Et2Zn (10–110 mol%) as additive. The distinctive feature of this addition across the C−C triple bond is its trans stereoselectivity. The radical nature of the silylzincation process is supported by diagnostic experiments and DFT calculations, which also corroborate the role played by steric effects to obtain that stereoselectivity. The procedure can be combined in one-pot with the copper(I)-mediated electrophilic substitution of the C(sp2)−Zn bond, with retention of the double bond geometry. This makes it valuable for the synthesis of stereodefined di- and trisubstituted vinylsilanes.
    Tags: POLE 1, Radical reactions, ROCS, Silylmetalation, Silylzinc reagents, Vinylsilanes, Zinc.
    Attachment Full Text PDF 5.6 Mb (source)

  • S. Topin-Ruiz, A. Mellinger, E. Lepeltier, C. Bourreau, J. Fouillet, J. Riou, G. Jaouen, L. Martin, C. Passirani, and N. Clere, “p722 ferrocifen loaded lipid nanocapsules improve survival of murine xenografted-melanoma via a potentiation of apoptosis and an activation of CD8+ T lymphocytes”, International Journal of Pharmaceutics, p. 120111, Jan. 2021.
    Abstract: Metastatic melanoma is a malignant tumor with a poor prognosis. Recent new therapeutics improved the survival of patients at a metastatic stage. However, the low response rate to immunotherapy, explained in part by resistance to apoptosis, needs to develop new strategies. The ferrocifen family represents promising bioorganometallic molecules for melanoma treatment since they show potent anticancer properties. The aim of this study is (i) to evaluate the benefits of a strategy involving encapsulated p722 in lipid nanocapsules (LNC) in B16F10 melanoma mice models and (ii) to compare the beneficial effects with an existing therapy such as anti-CTLA4 mAb. Interestingly, LNC-p722 induces a significant decrease of melanoma cell viability. In vivo data shows a significant improvement in the survival rate and a slower tumor growth with p722-loaded LNC in comparison with anti-CTLA4 mAb. Western blots confirm that LNC-p722 potentiates intrinsic apoptotic pathway. Treatment with LNC-p722 significantly activates CD8+ T lymphocytes compared to treatment with anti-CTLA4 mAb. This study uncovers a new therapeutic strategy with encapsulated p722 to prevent B16F10 melanoma growth and to improve survival of treated mice.
    Tags: apoptosis, CD8 T lymphocytes, CHEMBIO, Ferrocifen, metastatic melanoma, POLE 3.

  • A. Vessières, Y. Wang, M. J. McGlinchey, and G. Jaouen, “Multifaceted chemical behaviour of metallocene (M = Fe, Os) quinone methides. Their contribution to biology”, Coordination Chemistry Reviews, vol. 430, p. 213658, 2021.

  • T. Zhang, A. Solé‐Daura, H. Fouilloux, J. M. Poblet, A. Proust, J. J. Carbó, and G. Guillemot, “Reaction Pathway Discrimination in Alkene Oxidation Reactions by Designed Ti-Siloxy-Polyoxometalates”, ChemCatChem, vol. 13, no. 4, p. 1220-1229, 2021.
    Abstract: Titanium complexes of silanol functionalized polyoxometalates (THA)3[SbW9O33(RSiO)3Ti(OiPr)] (Ti-SiloxPOMs) catalyze alkene oxidation with tert-butyl hydrogen peroxide (TBHP). However catalytic activity and product distribution in the oxidation of allylic alcohols are shown to depend on the steric surrounding generated by the SiloxPOM (R=tBu, iPr, nPr). Combined experimental and computational studies clarify how steric repulsions between the oxidant (tBu group) and the surrounding SiloxPOM govern the reaction pathways leading either to oxidation of the alcohol function (R=tBu) or to alkene epoxidation (R=nPr). Moreover, another consequence of this steric repulsive interactions is that outer-sphere mechanisms become competitive with the inner-sphere ones (coordination of allylic alcohol), whether for the oxidative dehydrogenation reaction or for the epoxidation reaction. In the case of unfunctionalized olefins (linear and cyclic), we show that reducing the bulkiness surrounding the active site leads to higher conversion to epoxide, emphasizing that these Ti-SiloxPOMs may behave as structural and functional models for metal single-site in Ti-Silicates.
    Tags: alkene, DFT, E-POM, mechanistic study, oxidation, POLE 2, polyoxotungstates, titanium.


  • Abdmouleh, Fatma, El Arbi, Mehdi, Hajer, Ben Saad, Jellali, Karim, Etata, Emna, Amara, Ibtissem Ben, Pigeon, Pascal, Hanen, Ben Hassen, Top, Siden, Jaouen, Gérard, Hammami, Riadh, Mamdouh, Ben Ali, and Gupta, Girish Kumar, “Antimicrobial, Antitumor and Side Effects Assessment of a Newly Synthesized Tamoxifen Analog”, Current Topics in Medicinal Chemistry, vol. 20, no. 25, p. 2281-2288, Sep. 2020.
    Abstract: Background: Tamoxifen citrate is a very prevalent drug marketed under several trade names like Apo-Tamox, Nolvadex, Tamec, Tamizam, and Tamoplex. This molecule is approved by the FDA for breast cancer treatment. Some studies have shown that tamoxifen has anti-tuberculosis and antiparasitic activities. Like any drug, tamoxifen possesses side effects, more or less dangerous. Aims: Basically, this work is a comparative study that aims to: primarily compare the antimicrobial and antitumor activities of tamoxifen and a newly synthesized tamoxifen analog; and to determine the molecule with lesser side effects. Methods: Three groups of mice were injected with tamoxifen citrate and compound 2(1,1-bis[4-(3- dimethylaminopropoxy)phenyl]-2-phenyl-but-1-ene dihydrochloride) at doses corresponding to C1 (1/10), C2 (1/50), and C3 (1/100) to compound 2 lethal dose (LD50 = 75 mg/kg) administered to adult mice. A group of noninjected mice served as a study control. Results: Experimental results suggest that compound 2 has better antitumor and antimicrobial activity than tamoxifen citrate besides its lower toxicity effects. Conclusion: The results obtained from the present study confirmed the antitumor and antimicrobial effect of tamoxifen citrate and its hematological side effects. Compound 2 seems to be more effective than tamoxifen citrate for antitumor and antimicrobial treatment while having less hematological side effects and less disruption of the blood biochemical parameters. These findings encourage us to perform further studies on compound 2 and test it for other therapeutic uses for which tamoxifen was found effective.
    Tags: POLE 3.

  • S. Alves, A. Paris, and E. Rathahao-Paris, “Mass spectrometry-based metabolomics for an in-depth questioning of human health”, in Advances in Clinical Chemistry, Elsevier, 2020, p. S0065242320300214.

  • N. Audureau, F. Coumes, J. - M. Guigner, T. P. T. Nguyen, C. Ménager, F. Stoffelbach, and J. Rieger, “Thermoresponsive properties of poly(acrylamide-co-acrylonitrile)-based diblock copolymers synthesized (by PISA) in water”, Polymer Chemistry, vol. 11, no. 37, p. 5998-6008, Sep. 2020.
    Abstract: In this present work, we report the synthesis of UCST-thermoresponsive diblock copolymers using reversible addition fragmentation chain transfer (RAFT) polymerization in aqueous media. A water-soluble poly(N,N-dimethylacrylamide) macromolecular chain transfer agent (PDMAc macroRAFT) is used to promote and control the copolymerization of acrylamide and acrylonitrile in water and obtain PDMAc-b-P(AAm-co-AN) diblock copolymers. The fAN,0 and the length of the thermosensitive block (DPn) are systematically varied, in order to study their influence on the thermoresponsiveness of the block copolymers. A good blocking efficiency is generally evidenced by size exclusion chromatography. Remarkably, amphiphilic copolymer nanoparticles are formed in situ for the highest fAN,0. This is indeed the first time that such particles are produced by a polymerization-induced self-assembly (PISA) process. The morphology of the in situ formed nanoparticles and their behavior with temperature are studied by means of dynamic light scattering (DLS), (cryogenic) transmission electron microscopy ((cryo-)TEM) and turbidimetry. Spherical and worm-like nanoparticles are formed which exhibit unexpected properties, such as an unprecedented heating-induced worm-to-sphere morphological transition in water.
    Tags: POLE 4, POLYMERES.
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  • P. Bayat, D. Lesage, and R. B. Cole, “Tutorial: Ion activation in tandem Mass spectrometry using ultra-high resolition spectroscopy”, Mass Spectrometry Reviews, p. mas.21623, Feb. 2020.

  • L. Bedoin, S. Alves, and J. - F. Lambert, “Origins of Life and Molecular Information: Selectivity in Mineral Surface-Induced Prebiotic Amino Acid Polymerization”, ACS Earth and Space Chemistry, p. acsearthspacechem.0c00183, Sep. 2020.

  • A.

    Beghennou, K. Passador, A. Passador, V. Corcé, S. Thorimbert, and C. Botuha, “Synthetic Strategy Studies for a Concise Access to Functionalized Pyrano[4,3-b]pyridin-7-ones: An Entry to Semi-Rigid Analogs of Antihistamines”, European Journal of Organic Chemistry, vol. 2020, no. 36, p. 5880-5889, Sep. 2020.
    Abstract: We report short and efficient syntheses of polyfunctionalized 5,8-dihydro-7H-pyrano[4,3-b]pyridin-7-ones and 1,4-dihydro-3H-pyrano[4,3-c]pyridin-3-ones which can be considered as new aza analogs of 3-isochromanones and as promising scaffolds for medicinal chemistry. Depending on the nature of the substituent, three different and complementary synthetic methodologies were used allowing the introduction of significant diversity in the substituent on the lactone ring of the pyranopyridinones. The selective α-arylation of nitrile (SNAr) and tert-butyl ester enolate (Pd catalyzed) followed by an acidic mediated lactonisation gives access to original C8-functionalized pyrano[4,3-b]pyridin-7-ones and a seleno-mediated cyclization to C1-functionalized pyrano[4,3-c]pyridin-3-ones. We have also applied the outlined synthetic methodologies to the preparation of potential semi-rigid analogs of antihistamines.
    Tags: Antihistamines, CHEMBIO, Pinner reaction, POLE 3, Pyridopyridinones, Seleno-mediated cyclization, δ-Lactone.
    Note Note
    <p>doi: 10.1002/ejoc.202001016</p>

  • Y. Ben M’Barek, T. Rosser, J. Sum, S. Blanchard, F. Volatron, G. Izzet, R. Salles, J. Fize, M. Koepf, M. Chavarot-Kerlidou, V. Artero, and A. Proust, “Dye-Sensitized Photocathodes: Boosting Photoelectrochemical Performances with Polyoxometalate Electron Transfer Mediators”, ACS Applied Energy Materials, vol. 3, no. 1, p. 163-169, Jan. 2020.

  • A. Benchohra, C. Méthivier, J. Landoulsi, D. Kreher, and R. Lescouëzec, “Electrospray ionization: an efficient approach to deposit polymetallic molecular switches onto gold surfaces”, Chemical Communications, vol. 56, no. 48, p. 6587-6589, 2020.
    Abstract: Electrospray ionization (EI) deposition is proven efficient in obtaining monolayers of a polymetallic charge transfer complex on gold surfaces. , Electrospray ionization (EI) deposition is proven efficient in obtaining monolayers of a polymetallic charge transfer complex on gold surfaces. The molecule's integrity is monitored by using PM-IRRAS and XPS. This approach broadens the perspective of molecular magnetic switch deposition, which is currently dominated by the thermal evaporation of monometallic spin crossover (SCO) complexes.
    Tags: ERMMES, POLE 2.

  • B. Bertrand, C. Botuha, J. Forté, H. Dossmann, and M. Salmain, “A bis-chelating (O^N^O)/(N^N) ligand for the synthesis of heterobimetallic Pt(II)/Re(I) complexes: tools for the optimization of a new class of Pt(II) anticancer agents.”, Chemistry – A European Journal, vol. 26, no. 56, p. 12846-12861, Jun. 2020.
    Abstract: The two independent (O^N^O) and (N^N) coordination sites of a newly synthesized bis 2-(hydroxyphenyl)-1,2,4-triazole platform have been exploited to prepare four monometallic neutral (O^N^O)Pt(II) complexes carrying DMSO, pyridine, triphenylphosphine or N-heterocyclic carbene (NHC) as fourth ligand. Then the second (N^N) coordination site was used to introduce an IR-active rhenium tricarbonyl entity, affording the four corresponding heterobimetallic neutral Pt(II)/Re(I) complexes as well as a cationic Pt(II)/Re(I) derivative. X-ray crystallographic studies showed that distortion of the organic platform occurred to accommodate the coordination geometry of both metal centers. No ligand exchange and no transchelation occurred upon incubation of the Pt(II) complexes in aqueous environment or in the presence of Fe(III), respectively. The ligand and the complexes antiproliferative activity was first screened on the triple negative breast cancer cell line MDA-MB-231. Then the IC 50 of the most active candidates was determined on a wider panel of human cancer cells (MDA-MB-231, MCF-7 and A2780) as well as on a non-tumorigenic cell line (MCF-10F). Low micromolar activities were reached for the complexes carrying a DMSO ligand, making them the first examples of highly active though hydrolytically stable Pt(II) complexes. Finally, the characteristic mid-IR signature of the Re(CO) 3 fragment in the Pt/Re heterobimetallic complexes was used to quantify their uptake in breast cancer cells.
    Tags: cancer, CHEMBIO, CSOB, heterobimetallic, pincer, platinum, POLE 3, rhenium.
    Note Note
    <p>doi: 10.1002/chem.202001752</p>

  • B. Bertrand, G. Gontard, C. Botuha, and M. Salmain, “Pincer-based heterobimetallic Pt(II)/Ru(II), Pt(II)/Ir(III) and Pt(II)/Cu(I) complexes: synthesis and evaluation antiproliferative properties”, European Journal of Inorganic Chemistry, vol. 2020, no. 35, p. 3370-3377, Sep. 2020.
    Abstract: Platinum pincer-based complexes [(O^N^O)Pt(L)] (L = DMSO, pyridine, triphenylphosphine or 1,3-dimethylbenzimidazol-2-ylidene) carrying an (N^N) coordination site were used as starting materials to synthesize a series of seven cationic heterobimetallic Pt(II)/Ru(II), Pt(II)/Ir(III) and Pt(II)/Cu(I) presenting a [( p- cymene)RuCl] + , a [(Cp*)IrCl] + (Cp* = ? 5 -pentamethylcyclopentadienyl) and a [(NHC iPr )Cu] + (NHC iPr = 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene) moiety respectively. The X-ray structure of one of the bimetallic Pt(II)/Ir(III) complexes showed a distortion of the organic platform to accommodate the coordination geometry of both metal centers as already observed for previous Pt(II)/Re(I) complexes. The antiproliferative activity of the complexes was first screened on the triple negative breast cancer cell line MDA-MB-231. Then the IC 50 of the most active candidates was determined on a wider panel of human cancer cells (MDA-MB-231, MCF-7 and A2780) as well as on a non-tumorigenic cell line (MCF-10A). The most toxic compound, namely the Pt(II)/Cu(I) heterobimetallic complex 4c showed an antiproliferative activity down to the nanomolar level.
    Tags: Bioorganometallic chemistry, cancer, CHEMBIO, heterobimetallic complexes, platinum, POLE 3, Synthesis.
    Note Note
    <p>doi: 10.1002/ejic.202000717</p>

  • P. Biais, O. Colombani, L. Bouteiller, F. Stoffelbach, and J. Rieger, “Unravelling the formation of BAB block copolymer assemblies during PISA in water”, Polymer Chemistry, vol. 11, no. 28, p. 4568-4578, Jul. 2020.
    Abstract: The mechanism of formation of associative BAB triblock copolymers through aqueous polymerization-induced self-assembly (PISA) is investigated for the first time, on copolymers constituted of a hydrophilic poly(N,N-dimethylacrylamide) block (PDMAc = block A) and a hydrophobic poly(diacetone acrylamide) block (PDAAm = block B). Such BAB copolymers tend to form bridged micelles/networks, which was expected to make the PISA process much more complex than for conventional diblock copolymers. Kinetic monitoring, light scattering analyses and macroscopic observations allowed identifying crucial parameters that influence the polymerization and the final dispersion properties, notably the stirring of the polymerization medium, the macroRAFT agent concentration, its ionization degree (related to the pH) and its Z group alkyl chain length.
    Tags: POLE 4, POLYMERES.
    Attachment Full Text PDF 2.7 Mb (source)

  • A. Bordes, A. Poveda, T. Troadec, A. Franconetti, A. Ardá, F. Perrin, M. Ménand, M. Sollogoub, J. Guillard, J. Désiré, R. Tripier, J. Jiménez-Barbero, and Y. Blériot, “Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog”, Organic Letters, vol. 22, no. 6, p. 2344-2349, Mar. 2020.

  • G. Bouhalleb, A. Meddeb, N. F. Bourguiba, J. Legros, G. Poli, and F. Rezgui, “First Zinc Bromide Promoted Annulative Domino Reactions between Enamines and Cyclic Morita–Baylis–Hillman Alcohols: Synthesis of N,O-Ketals”, Synlett, vol. 31, no. 13, p. 1282-1286, Aug. 2020.
    Abstract: A new efficient ZnBr2-mediated annulative domino reaction between enamines and cyclic Morita–Baylis–Hillman (MBH) alcohols is disclosed. The process involves a tandem sequence (intermolecular conjugate addition of enamines to MBH alcohols and intramolecular nucleophilic addition of the hydroxyl moiety to the transiently generated iminium ion), affording the corresponding N,O-ketals diastereoselectively in good yields.
    Tags: conjugate addition, domino reactions, enamines, ketals, Key words MBH alcohol, N,O, POLE 1, ROCS, zinc bromide.
    Attachment Full Text PDF 233.1 kb (source)

  • A. Cartier, E. Levernier, A. - L. Dhimane, T. Fukuyama, C. Ollivier, I. Ryu, and L. Fensterbank, “Synthesis of Alip

    hatic Amides through a Photoredox Catalyzed Radical Carbonylation Involving Organosilicates as Alkyl Radical Precursors”, Advanced Synthesis & Catalysis, vol. 362, no. 11, p. 2254-2259, 2020.
    Abstract: Alkyl radicals, from primary to tertiary, formed by photocatalyzed oxidation of organosilicates, are involved efficiently in radical carbonylation with carbon monoxide (CO), in the presence of various amines and CCl4, leading to a variety of amides in moderate to good yields.
    Tags: Carbonylation, MACO, multi-component reaction, photooxidative catalysis, POLE 1, radical/polar, silicates.
    Attachment Full Text PDF 4.8 Mb (source)

  • M. S. Centellas, M. Piot, R. Salles, A. Proust, L. Tortech, D. Brouri, S. Hupin, B. Abécassis, D. Landy, C. Bo, and G. Izzet, “Exploring the self-assembly of dumbbell-shaped polyoxometalate hybrids, from molecular building units to nanostructured soft materials”, Chemical Science, vol. 11, no. 40, p. 11072-11080, Oct. 2020.
    Abstract: The formation of hierarchical nanostructures using preformed dumbbell-like species made of covalent organic–inorganic polyoxometalate (POM)-based hybrids is herein described. In this system, the presence of charged subunits (POM, metal linkers, and counter ions) in the complex molecular architecture can drive their aggregation, which results from a competition between the solvation energy of the discrete species and intermolecular electrostatic interactions. We show that the nature of the POM and the charge of the metal linker are key parameters for the hierarchical nanoorganization. The experimental findings were corroborated with a computational investigation combining DFT and molecular dynamics simulation methods, which outlines the importance of solvation of the counter ion and POM/counter ion association in the aggregation process. The dumbbell-like species can also form gels, in the presence of a poorer solvent, displaying similar nanoorganization of the aggregates. We show that starting from the designed molecular building units whose internal charges can be controlled by redox trigger we can achieve their implementation into soft nanostructured materials through the control of their supramolecular organization.
    Tags: E-POM, POLE 2.
    Attachment Snapshot 798 kb (source)
    Attachment Full Text PDF 943.8 kb (source)

  • Y. Chang, Y. Yuan, Q. Zhang, Y. Rong, Y. Yang, M. Chi, Z. Liu, Y. Zhang, P. Yu, and Y. Teng, “Effects of an isatin derivative on tumor cell migration and angiogenesis”, RSC Advances, vol. 10, no. 2, p. 1191-1197, 2020.
    Abstract: Compound 5-61 , a 5-(2-carboxyethenyl)isatin derivative was previously shown to have potent anticancer activity. Its effect on angiogenesis was further explored in this study. , Compound 5-61 , a 5-(2-carboxyethenyl)isatin derivative was previously shown to have potent anticancer activity. Its effect on angiogenesis was further explored in this study. Notably, 5-61 showed selective cytotoxicity against liver hepatocellular carcinoma HepG-2 cells (IC 50 = 7.13 nM). 5-61 powerfully induced apoptosis and G 2 /M phase arrest as well as inhibited the migration of HepG2 cells. Additionally, 5-61 clearly diminished tube formation and the actin arrangement in HUVECs. The physiological anti-angiogenic effects of 5-61 were further assessed by chick chorioallantoic membrane assays in vivo . The effects exerted by 5-61 were found to be mediated by VEGF along with its downstream signaling pathways including the PI3K/Akt/mTOR pathway and mitogen-activate protein kinase pathways (ERK). These results suggested that 5-61 is a potential tumor angiogenesis inhibitor that functions by interrupting the auto-phosphorylation of AKT, mTOR, and ERK 1/2.
    Tags: GOBS, POLE 3.

  • Y. Chen, X. Wang, Y. Zhu, L. Si, B. Zhang, Y. Zhang, L. Zhang, D. Zhou, and S. Xiao, “Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor”, Molecular Pharmaceutics, vol. 17, no. 7, p. 2546-2554, Jul. 2020.

  • R. B. Cole, P. Bayat, J. S. Murray, C. Albers, and D. Brombach, ““Conformation pinning” by anion attachment enabling separation of isomeric steroid monomers by ion mobility spectrometry”, Journal of Mass Spectrometry, vol. 55, no. 12, Dec. 2020.

  • F. Coumes, M. Balarezo, J. Rieger, and F. Stoffelbach, “Biobased Amphiphilic Block Copolymers by RAFT-Mediated PISA in Green Solvent”, Macromolecular Rapid Communications, vol. 41, no. 9, p. 2000002, 2020.
    Abstract: Biobased amphiphilic diblock copolymers are prepared thanks to the combination of reversible addition–fragmentation transfer (RAFT) polymerization and polymerization-induced self-assembly (PISA) in an eco-friendly solvent mixture. First, the formation of a poly(acrylic acid) macroRAFT agent (PAA-TTC) is performed in water at 70 °C. Then, in a series of experiments, the PAA-TTC macroRAFT agent is used directly, without purification, as both chain transfer agent and stabilizing agent in the RAFT-PISA of menthyl acrylate (MnA) in dispersion in an ethanol/water mixture. The polymerizations of MnA are fast with high final conversions and well-controlled amphiphilic diblock copolymers are synthesized. Stable, sub-micrometric spherical particles composed of the diblock copolymers are formed. The influence of the monomer concentration and the length of the solvophobic block on the diameter of the self-assemblies is studied by means of dynamic light scattering and cryogenic transmission electron-microscopy.
    Tags: amphiphilic copolymers, biobased monomers, dispersion polymerization, PISA, POLE 4, POLYMERES, RAFT.
    Attachment Full Text PDF 1.3 Mb (source)

  • Y. Cui, Y. Mao, J. Mao, and Y. Zhang, “Smart regioselectivity towards mono 6-hydroxyl α-cyclodextrin amphiphilic derivatives”, RSC Advances, vol. 10, no. 18, p. 10695-10702, 2020.
    Abstract: A smart regioselective CD modification is described. For mono 6-hydroxyl and penta-alkyl coexistence on the primary face of α-CD, no additional catalysis or enzyme process are needed, just via adjustment of the ratio of alkali to alkylation agent. , Following the trend of eco-friendly development, a smart regioselective modification is described herein, for mono 6-hydroxyl and penta-alkyl coexistence on the primary face of α-cyclodextrins with no additional catalysis or no enzyme process, just via the adjustment of the ratio of alkali to alkylation agent, with good yields. The novel procedure minimized the tedious protection, deprotection steps and provided useful intermediates for further cutting edge research. Thus, the scope of green and economical access is extended from penta-pentenyl substitution to C 4 –C 6 alkyl group substitution. It was speculated that the mechanism might be controlled by the concentration of alkali in the system and the steric effects of the electrophilic reagent RBr.
    Tags: GOBS, POLE 3.

  • L. Cunningham, Y. Wang, C. Nottingham, J. Pagsulingan, G. Jaouen, M. McGlinchey, and P. J. Guiry, “Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells”, ChemBioChem, vol. 21, no. 20, p. 2974-2981, 2020.
    Abstract: The design and first enantioselective synthesis of a series of chiral ferrocifens and ferrociphenols was realised via enantioselective palladium-catalysed intramolecular direct C?H bond activation followed by McMurry coupling. Biological evaluation revealed moderate anticancer activities on breast cancer cells and evidence of chiral discrimination between enantiomers. Treatment of these novel ferrocifens with Ag 2 O revealed that these systems are unable to form a neutral quinone methide, yet still demonstrate marked antiproliferative properties versus both the hormone-dependent MCF-7 and hormone-independent MDA-MB-231 cell lines. This bioactivity arises from two mechanisms: Fenton-type chemistry and the anti-estrogenic activity associated with the tamoxifen-like structure.
    Tags: anti-cancer activity, asymmetric synthesis, CHEMBIO, Ferrocene, McMurry coupling, POLE 3.
    Note Note
    <p>doi: 10.1002/cbic.202000311</p>
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    F. D'Agosto, J. Rieger, and M. Lansalot, “RAFT-Mediated Polymerization-Induced Self-Assembly”, Angewandte Chemie International Edition, vol. 59, no. 22, p. 8368-8392, 2020.
    Abstract: After a brief history that positions polymerization-induced self-assembly (PISA) in the field of polymer chemistry, this Review will cover the fundamentals of the PISA mechanism. Furthermore, this Review will also give an overview of some of the features and limitations of RAFT-mediated PISA in terms of the choice of the components involved, the nature of the nanoobjects that can be obtained and how the syntheses can be controlled, as well as some potential applications.
    Tags: block copolymers, heterogeneous polymerization, morphology, PISA, POLE 4, POLYMERES, RAFT.
    Attachment Full Text PDF 4.4 Mb (source)

  • A. Delvaux, E. Rathahao‐Paris, and S. Alves, “An emerging powerful technique for distinguishing isomers: Trapped Ion Mobility Spectrometry ‐ Time‐of‐Flight Mass Spectrometry for a rapid characterization of estrogen isomers”, Rapid Communications in Mass Spectrometry, Aug. 2020.

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