Thèmes de recherches- Etudes fondamentales mécanismes d’ionisation par électrospray et MALDI
- Attachement d’anions en spectrométrie de masse
- Distributions des états de charge en électrospray et MALDI
- Interactions non-covalentes sondées par la spectrométrie de masse
- Couplage électrospray-NEMS
- Métabolomique
- Réactivité chimique en phase gazeuse.
Recherche actuelle :- Attachement régiosélectif d’anions pour l’analyse des stéroïdes.
- Un nouveau modèle "Best Match" pour caractériser les adduits protéiques survivants en électrospray.
- Métabolisme des "glyceollins."
- Découverte des nouvelles matrices pour le MALDI.
Résultats Récents :
Figure 1a-c. Evidence of regioselective anion attachment shown in blow-ups of negative mode electrospray CID product ion mass spectra showing m/z 315–322 (region of deprotonated molecules) from precursor adducts of d4-pregnenolone :
(a) acetate adduct at m/z 379 ;
(b) bicarbonate adduct at m/z 381 ;
(c) fluoride adduct at m/z 339.
(d)Negative mode ESI-MS/MS product ion mass spectrum of fluoride adduct precursor (m/z 335) of pregnenolone.
Parcours Scientifique : - Professeur Des Universités, Université Pierre et Marie Curie, 2011- present
- Chancellor’s Research Professor, University of New Orleans 2011
- University Research Professor, University of New Orleans 2002 – 2011
- Professor of Chemistry, University of New Orleans 1997 - 2002
- Associate Professor, University of New Orleans 1993 - 1997
- Assistant Professor, University of New Orleans 1989 - 1993
- Post-Doctoral Research Associate, Université Paris (VI), France 9/86 - 9/87
- Ph.D., University of North Carolina at Chapel Hill, 8/86 (Analytical Chemistry)
- M.S., University of Illinois at Champaign/Urbana, 8/82 (Analytical Chemistry)
- B.A., Grinnell College, Grinnell, IA, 5/78 Chemistry
- B.A., Grinnell College, Grinnell, IA, 5/78 French
Choix de publications récents :
 Q. Dumont, M. Barcenas, H. Dossmann, I. Bailloux, C. Buisson, N. Mechin, A. Molina, F. Lasne, N. S. Rannulu, R. B. Cole, "Improved Steroids Detection and Evidence for Their Regiospecific Decompositions Using Anion Attachment Mass Spectrometry" Analytical Chemistry (2016) 88 : 3585-3591.
J. Shraberg, S. W. Rick, N. Rannulu, R. B. Cole "A study of procyanidin binding to Histatin 5 using Electrospray Ionization Tandem Mass Spectrometry (ESI-MS/MS) and molecular simulations" Physical Chemistry Chemical Physics (2015) 17 : 12247-12258.
B. P. Pozniak, R. B. Cole, Critical Insight "Perspective on Electrospray Ionization and its Relation to Electrochemistry" J. Am. Soc. Mass Spectrom., (2015) 26 : 369-385.
S. S. Quadri, R. E. Stratford, S. M. Boue, R. B. Cole "Identification of Glyceollin Metabolites Derived from Conjugation with Glutathione and Glucuronic Acid in Male ZDSD Rats by Online Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry", Journal of Agricultural and Food Chemistry (2014) 62 : 2692-2700.
X. Liu, R. B. Cole "“Best Match” Model and Effect of Na+/H+ Exchange on Anion Attachment to Peptides and Stability of Formed Adducts in Negative Ion Electrospray Mass Spectrometry" J. Am. Soc. Mass Spectrom., (2014) 25 : 204-213.
N. Rannulu, R. B. Cole “Novel Fragmentation Pathways of Anionic Adducts of Steroids Formed by Electrospray Anion Attachment Involving Regioselective Attachment, Regiospecific Decompositions, Charge-Induced Pathways and Ion-Dipole Complex Intermediates” J. Am. Soc. Mass Spectrom. (2012) 23 : 1558-1568.
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