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Annunziata Alfonso


Sorbonne Université

Institut Parisien de Chimie Moléculaire(UMR_8232), équipe ChemBio barre 33-43, étage 4, pièce 410, Campus Pierre et Marie Curie - 4 place Jussieu 75005 PARIS


  • Synthesis and characterization of organometallic complexes with anticancer properties
  • Fluorescent complexes for cellular imaging
  • Study of the chemical reactivity of organometallic complexes with biological molecules
  • Cytotoxic properties of metal complexes on cellular models


  • 2018-2021 : 2018-2021: European PhD at the University Federico II (Napoli, Italy). Research project on the synthesis and studies of the anticancer properties of novel glycoconjufìgate organometallic complexes (Pt, Ru, Au). (Under the supervision of Prof. Francesco Ruffo and Dr. Maria Elena Cucciolito).
  • 2016-2018: Master’s degree (M.Sc.) in Chemical Sciences (cum Laude), University Federico II (Napoli, Italy).
  • 2013-2016: Bachelor’s degree (B.Sc.) in Chemistry, University Federico II (Napoli, Italia).


  • Mar. 2022-: Postdoc in Chembio team (under the supervision of Dr. Michèle Salmain), on the study of half-sandwich iridium complexes for anti-cancer and cellular imaging applications (IPCM, Sorbonne University, Paris, France).
  • Oct. 2020- April 2021: Research period at the Ecole Polytechnique Fédérale de Lausanne (EPFL, Lausanne, Switzerland) in the group of Prof. Paul J. Dyson, on the synthesis and study of ruthenium arene complexes as anticancer agents.
  • Sept 2016 – June 2018: Master’s internship under the supervision of Prof. Francesco Ruffo and Dr. Maria Elena Cucciolito at the University Federico II (Napoli, Italy) on the synthesis and the study of the catalytic properties of Fe(III) complexes for oxidation processes.
  • Oct. 2017: Internship in Prof. Alceo Macchioni group at the University of Perugia (Perugia, Italy) on the properties of Fe(III) complexes as water oxidation catalysts (WOCs).
  • Mar. 2016 – June 2016: B.Sc.’s internship under the supervision of Prof. Francesco Ruffo at the University Federico II (Napoli, Italy) on the synthesis and characterization of Mn(II) complexes with tri- and tetra-aza macrocyclic ligands.


  • S. La Manna, M. Leone, I. Iacobucci, A. Annunziata, C. Di Natale, E. Lagreca, F. Ruffo, A. Merlino, M. Monti, D. Marasco, “A glucosyl platinum(II) complex inhibits the aggregation of the C-terminal region of Aβ peptide”, Inorg. Chem. 2022, 61, 8, 3540–3552
  • A. Annunziata, D. Liberti, E. Bedini, M.E. Cucciolito, D. Loreto, D.M. Monti, A. Merlino and F. Ruffo, “Square-planar vs. Trigonal bipyramidal geometry in Pt(II) complexes containing triazole-based glucose ligands as potential anticancer agents“, Int. J. Mol. Sci., 2021, 22, 8704
  • A. Annunziata, M. E. Cucciolito, R. Esposito, S. Traboni, A. Tuzi, P.H.M. Budzelaar and F. Ruffo, “Oxidative Addition of α-Glycosyl Halides to a Platinum(0) Olefin Complex: Stereochemistry of Pt−C Bond Formation“, Eur. J. Inorg. Chem., 2021, 534-539
  • A. Annunziata, M.E. Cucciolito, P. Imbimbo, A. Silipo and F. Ruffo,” A hydrophilic olefin Pt(0) complex containing a glucoconjugated 2-iminopyridine ligand: Synthesis, characterization, stereochemistry and biological activity” Inorg. Chim. Acta, 2021, 516, 120092
  • R. Esposito, M. Melchiorre, A. Annunziata, M.E. Cucciolito and F. Ruffo, “Emerging catalysis in biomass valorisation: simple Zn(II) catalysts for fatty acids esterification and transesterification”, Chem. Cat. Chem., 2020, 12, 5858-5879
  • • F. Tresin, V. Stroppa, M. Baron, A. Biffis, A. Annunziata, L. D’Elia, D.M. Monti, F.Ruffo, M.Roverso, P. Sgarbossa, S.Bogialli and C. Tubaro, “Synthesis and Biological Studies on Dinuclear Gold(I) Complexes with Di-(N-Heterocyclic Carbene) Ligands Functionalized with Carbohydrates”, Molecules, 2020, 25, 3850.
  • • A. Annunziata, A. Amoresano, M.E. Cucciolito, R. Esposito, G. Ferraro, I. Iacobucci, P. Imbimbo, R. Lucignano, M. Melchiorre, M. Monti, C. Scognamiglio, A. Tuzi, D. M. Monti, A. Merlino, and F. Ruffo, “Pt(II) versus Pt(IV) in Carbene Glycoconjugate Antitumor Agents: Minimal Structural Variations and Great Performance Changes”, Inorg. Chem., 2020, 59, 4002-4014.
  • • A. Annunziata, M.E. Cucciolito, R. Esposito, G. Ferraro, D.M. Monti, A. Merlino and F. Ruffo, “Five-Coordinate Platinum(II) Compounds as Potential Anticancer Agents”, Eur. J. Inorg. Chem., 2020, 918-929.
  • • A. Annunziata, M.E. Cucciolito, R. Esposito, P. Imbimbo, G. Petruk, G. Ferraro, V. Pinto, A. Tuzi, D.M. Monti, A. Merlino and F. Ruffo, “A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex”, Dalton Trans., 2019, 48, 7794-7800.
  • • A. Annunziata, R. Esposito, G. Gatto, M.E., A. Tuzi, A. Macchioni and F. Ruffo, “Iron(III) Complexes with Cross-Bridged Cyclams: Synthesis and Use in Alcohol and Water Oxidation Catalysis”, Eur. J. Inorg. Chem., 2018, 3304-3311.
  • • G. Di Mauro, A. Annunziata, M.E. Cucciolito, M. Lega, S. Resta, A. Tuzi and F. Ruffo, “N,N′-diethyl and N-ethyl,N′-methyl glyoxal-bridged cyclams: synthesis, characterization, and bleaching activities of the corresponding Mn(II) complexes”, Transit. Met. Chem., 2017, 42, 427-433.