Supervisory authorities



Home > Directory > CSOB

Ingénieur de Recherche CNRS

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 42-43 4ème étage

Tel:33(0)1 44 27 51 18


Research interests:

Mass spectrometry applied to Glycomic and supra/-macromolecular assemblies.

Current research:

  • Analysis and structural deciphering of complex oligo-/polysaccharides.
  • Characterization of supra- and macromolecular assemblies.
  • Study of non covalent complexes involving biomolecules and/or metals

Recent results:

  • Characterization of polycationic carbohydrates based non-viral gene delivery agents combining CID, HCD and ETD tandem mass spectrometry.

  • Synthesis and characterization of biomimetic nanotubes based on cyclodextrins for ion-channel applications.

  • Development of an extraction method for sulfated oligosaccharides from polyacrylamide gel for their mass spectrometry analysis.

Scientific career

  • Since 2016: CNRS Research engineer in chemical analysis. Institut Parisien de Chimie moléculaire (CNRS UMR8232), Sorbonne Universités, UPMC.
  • 2011-2014: Ph.D in analytical chemistry at Université d’Evry Val d’Essonne. Development of novel analytical methods for bio-actives anionic oligosaccharides by mass spectrometry.
  • 2006-2015: engineer in analytical techniques for biomolecules.
    Laboratoire analyse et modélisation pour la biologie et l’environnement (CNRS UMR8587). Université d’Evry Val d’Essonne. Development of novel methodologies for biomolecules analysis by mass spectrometry.
  • 2006: Engineering school Diploma, specialized in analytical chemistry. CNAM (Conservatoire National des Arts et Métiers), Paris. Establishment of a multiresidue method for the dosage of pesticides by gas chromatography hyphenated to mass spectrometry.

Selected publications:

  1. Interactions between shape-persistent macromolecules as probed by AFM. Blass J., Brunke J., Emmerich F., Przybylski C., Bennewitz R., Wenz G., Albrecht M. Beilstein Journal of Organic Chemistry (2017); 13: 938-951.
  2. Toward a suitable structural analysis of gene delivery carrier based on polycationic carbohydrates by electron transfer dissociation tandem mass spectrometry. Przybylski C., Benito Juan M., Bonnet V., Ortiz Mellet C., García Fernández José M. Analytica Chimica Acta. (2016); 948:62-72.
  3. Biomimetic nanotubes based on cyclodextrins for ion-channel applications. Mamad-Hemouch H, Ramoul H., Abou Taha M., Huin C., Bacri L., Przybylski C., Oukhaled A., Thiébot B., Patriarche G., Jarroux N., Pelta J. Nanoletters. (2015); 15(11): 7748-7754.
  4. Analysis of a polydisperse polyrotaxane based on poly(ethylene oxide) and α-cyclodextrins using nanoelectrospray and LTQ-Orbitrap. Przybylski C., Jarroux N. Analytical Chemistry. (2011); 83(22): 8460-8467.
  5. HABA-based ionic liquid matrices for UV-MALDI-MS analysis of heparin and heparan sulfate oligosaccharides. Przybylski C., Gonnet F., Bonnaffé D., Lortat-Jacob H., Daniel R. Glycobiology. (2010); 20(2): 224-234.