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Université Pierre et Marie Curie Paris 6,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 33-43 4ème étage. case 229
Équipe Chembio


Professional Experience

April 2016 – today : Postdoctoral Research contract, Université Pierre et Marie Curie Paris 6 (Research group of Prof. SergeThorimbert)
Objective : Michem founded project in Design of polymer-based theranostic agents for imaging and targeted delivery of antitumor metallodrugs
February 2014 – January 2016 : Postdoctoral Research contract, Chimie ParisTech (Research group of Prof. Christophe M. Thomas)
Objective : ANR founded project in Supramolecular catalysts based on dynamic hydrogen-bonded assemblies apply in asymmetric hydrosilylation and polymerization catalysis (Publication in preparation)
March 2012 - March 2013 : Postdoctoral Research contract, Université de Montréal (Research group of Prof. A. B. Charrette), founded by the Swiss National Science Foundation
Objective : Synthesis of recyclable catalysts supported on tétraarylphosphonium for homogeneous asymmetric catalysis. (Green Chem., 2015, 17, 3255-3259)
February - August 2007 : Industrial R&D internship at Novartis Pharma, Basel (CH) Department of Chemical and Analytical Development
Objective : Development of a robust and practical process for the Darzens condensation (Synthesis 2008, 8, 1221-1126)


2007 - 2012 : Philosophiae doctor (Ph. D.) in Bio-inorganic Chemistry, University of Basel (CH) under the supervision of Prof. Thomas R. Ward (Universität Basl, Switzerland)
Objective : Creation of artificial metalloenzymes based on biotin-streptavidin technology for DNA recognition and homogeneous asymmetric catalysis. (4 publications)
2005 - 2007 : MSc in Professional Chemistry, Université Montpellier 2 (F) ; Bioactives Molecules, Synthesis, Screening et Purification, with honors (14.2/20)

Scientific Background

Chemistry :
• Organometallic Chemistry : Homogeneous asymmetric catalysis, synthesis of transition metal complexes, reactions performed under controlled atmosphere (schlenk lines, glove box), complex characterization.
• Organic Chemistry : Multi-step synthesis, parallel reactions (Radleys reactor), stereoselective organic synthesis
Biology :
• Anticancer Research : Synthesis of organometallic complexes (Pt, Ru) for DNA recognition
• Protein Engineering : Production, purification and characterization of proteins, creation of metalloenzymes


« Development of a robust and practical process for the Darzens condensation and α,β-epoxide rearrangement : scope and limitations of the methodology », J. M. Zimbron, M.Seeger-Weibel, H. Hirt, F. Gallou, Synthesis 2008, 8, 1221-1226.
« Chemo-genetic optimization of DNA recognition by metallodrugs using a presenter protein strategy » J. M. Zimbron, A. Sardo, T. Heinisch, T. Wohlschlager, J. Gradinaru, C. Massa, T. Schirmer, M. Creus, T. R. Ward, Chem. Eur. J. 2010, 16, 12883-12889.
« Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines » M. Dürrenberger, M. ; Heinisch, T. ; Wilson, Y. M. ; Rossel, T. ; Nogueira, E. ; Knörr, L. ; Mutschler, A. ; Kersten, K. ; Zimbron, M. J. ; Pierron, J. ; Schirmer, T. ; T. R. Ward, Angew. Chem. Int. Ed. 2011, 50, 3026.
« A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin-streptavidin technology », J. M. Zimbron, Tillmann Heinisch, Maurus Schmid, Didier Hamels, Elisa S. Nogueira, Markus Meuwly, Tilman Schirmer and T. R. Ward, J. Am. Chem. Soc. 2013, 135 (14), 5384-5388.
« Expanding the Chemical Diversity in Artificial Imine Reductases Based on the Biotin-Streptavidin Technology », T. Quinto, F. Schwizer, J. M. Zimbron, A. Morina, V. Köhler, T. R. Ward,. ChemCatChem, 2014, 6, 1010-1014.
« Noyori-Ikariya Catalyst Supported on Tetraarylphosphonium for Asymmetric Transfer Hydrogenation in Water », J. M. Zimbron, Maxime Dauphinais, André B. Charette, Green Chem., 2015, 17, 3255-3259.

Languages :
• French and Spanish : Mother tongs
• English : Spoken and written
Softwares :
• Scifinder, Reaxys, Chemdraw, VMD, MestReNova,Top Spin, EndNote, Inventory, eNovalys, MS office